Source:HEK293cells
Content:5µgOverview
ANGPTL5standsforangiopoietin-like5,alsotermedangiopoietin-likeprotein5orangiopoietin-relatedprotein5.HumanANGPTL5isarecombinantproteinoptimizedforuseincellculture,differentiationstudies,andfunctionalassays.
Applications
HumanANGPTL5maybeusedforavarietyofapplications,including:
- Exvivoexpansionofhumanhematopoieticstemcells.
- Studiesoflipoproteinmetabolismorangiogenesis.
Details
Backgroundinformation
Angiopoietin-like5(ANGPTL5),alsocalledangiopoietin-likeprotein5orangiopoietin-relatedprotein5,isasecretedfactorwithhighhomologytoangiopoietinswhichareimportantregulatorsofangiogenesis.Angiopoietinsbindtotheangiopoietin-specificreceptorTIE-2,whereasangiopoietin-likeproteinsdonotbindtothisreceptor.ThereceptorforANGPTL5isnotyetknown.Duetoacoiled-coildomain,whichcaninteractwiththeextracellularmatrix,theyexistprimarilyashomooligomers.Angiopoietin-likeproteinsarepotentregulatorsofangiogenesiseitherproangiogenicorantiangiogenicfactors,suggestingthattheirreceptorsmaybeexpressedonendothelialcells.Theyalsoshowpleiotropiceffectsoncellsofotherlineages,suchasskincellsandchondrocytes.Angiopoietin-likeproteinsplayaroleinlipidandtriglyceridemetabolismandvertebratedevelopment.IthasbeenshownthatANGPTL5stimulatestheexvivoexpansionofhumancordbloodhematopoieticstemcells.
Qualitydescription
Research-gradecytokinesaresuitableforawidevarietyofcellcultureapplications.Theyaresterile-filteredpriortolyophilization.Generally,endotoxinlevelsare<0.1ng/μg(<1EU/μg),andpuritiesare>95%.