Source:CHOcells
Content:10µgOverview
BMP-7standsforbonemorphogeneticprotein7.HumanBMP-7isarecombinantproteinoptimizedforuseincellculture,differentiationstudies,andfunctionalassays.
Applications
HumanBMP-7canbeusedforavarietyofapplications,including:
- Mesenchymalcellcultures.
- Invitrostudiesofboneandcartilagedevelopment.
- InvestigationofSMADsignaling.
Details
Backgroundinformation
Bonemorphogeneticprotein7(BMP-7)belongstotheBMPfamilyandtothetransforminggrowthfactorβ(TGF-β)superfamily.BMPsregulateboneandcartilagedevelopmentandremodeling,actingoncellproliferation,differentiation,andapoptosisofmesenchymalcells.ThematureformofBMP-7isgeneratedbycleavageofthesignalpeptideandpropeptide,andhomo-dimerization.BMP-7isinvolvedinosteoblastdifferentiation,butalsointheregulationoftissueandorgandevelopmentduringembryogenesisofdifferentspecies,anditisexpressedinmanyorgans.BMP-7isextensivelyinvestigatedforclinicalapplications,andrecombinantBMP-7isusedinboneregeneration,bonegraft,anddentalreconstruction.RecombinantHumanBMP-7correspondstothematureformofBMP-7.
AlkalinephosphataseactivityassayusingMC3T3-E1cells
researchgrade:≥1×104U/mg
Qualitydescription
Research-gradecytokinesaresuitableforawidevarietyofcellcultureapplications.Theyaresterile-filteredpriortolyophilization.Generally,endotoxinlevelsare<0.1ng/μg(<1EU/μg),andpuritiesare>95%.Thebiologicalactivityistestedinappropriatebioassays.