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Tocris/SR 95531 hydrobromide/1262/50/50 mg

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货号: 1262/50

品牌: Tocris

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Description: Selective, competitive GABA_A receptor antagonist

Alternative Names: Gabazine

Chemical Name: 6-Imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid hydrobromide

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective, competitive GABA_A receptor antagonist. Displaces [³H]-GABA from rat brain membranes with a K_i of 150 nM. Unlike bicuculline, selectively antagonizes GABA-induced Cl^- currents with little action on pentobarbitone-induced currents. Also acts as a low affinity glycine receptor antagonist.

Compound Libraries

SR 95531 hydrobromide is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	368.23
Formula	C₁₅H₁₇N₃O₃.HBr
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	104104-50-9
PubChem ID	11056106
InChI Key	VVDXNJRUNJMYOZ-DHXVBOOMSA-N
Smiles	Br.COC1=CC=C(C=C1)C1=NN(CCCC(O)=O)C(=N)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	phosphate buffered saline	1.84	5
	DMSO	36.82	100
	ethanol	7.36	20
	water	9.21	25

Preparing Stock Solutions

The following data is based on the product molecular weight 368.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.72 mL	13.58 mL	27.16 mL
5 mM	0.54 mL	2.72 mL	5.43 mL
10 mM	0.27 mL	1.36 mL	2.72 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Beato et al (2007) The kinetics of inhibition of rat recombinant heterotrimeric α1β glycine receptors by the low affinity antagonist SR-95531. J.Physiol. 580 171 PMID: 17218350

Heaulme et al (1986) Biochemical characterization of the interaction of three pyridazinyl-GABA derivatives with the GABA_A receptor site. Brain Res. 384 224 PMID: 3022866

Uchida et al (1996) The differential antagonism by bicuculline and SR95531 of pentobarbitone-induced currents in cultured hippocampal neurons. Eur.J.Pharmacol. 307 89 PMID: 8831109

Keywords: SR 95531 hydrobromide, supplier, Selective, competitive, GABAA, receptor, antagonists, Receptors, SR95531, hydrobromide, Gabazine, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience

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