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Tocris/Apigenin/1227/50/50 mg

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货号: 1227/50

品牌: Tocris

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Description: Protein kinase inhibitor

Chemical Name: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Purity: ≥97% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Protein kinase inhibitor. Suppresses tumor-promoting effects of TPA and exhibits antiproliferative activity in human breast cancer cells (IC₅₀ values are 59.44 and 31.15 μM at 24 and 72 hrs respectively). Activates both the intrinsic and extrinsic apoptotic pathways and displays anti-inflammatory, hypotensive, antispasmodic and antioxidant properties in vivo.

Technical Data

M. Wt	270.2
Formula	C₁₅H₁₀O₅
Storage	Desiccate at +4°C
Purity	≥97% (HPLC)
CAS Number	520-36-5
PubChem ID	5280443
InChI Key	KZNIFHPLKGYRTM-UHFFFAOYSA-N
Smiles	OC1=CC=C(C=C1)C1=CC(=O)C2=C(O1)C=C(O)C=C2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility	Soluble to 50 mM in DMSO

Solubility

Soluble to 50 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 270.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.7 mL	18.5 mL	37.01 mL
5 mM	0.74 mL	3.7 mL	7.4 mL
10 mM	0.37 mL	1.85 mL	3.7 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Choi et al (2009) Apigen induces apoptosis through a mitochondria/caspase-pathway in human breast cancer MDA-MB-453 cells. J.Clin.Biochem.Nutr. 44 260 PMID: 19430615

Jin et al (2009) Apigenin protects endothelium-dependent relaxation of rat aorta against oxidative stress. Eur.J.Pharmacol. 616 200 PMID: 19549516

Kuo and Yang (1995) Reversion of v-H-ras-transformed NIH3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes. Biochem.Biophys.Res.Commun. 212 767 PMID: 7626110

Lin et al (1997) Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin. J.Cell.Biochem.Suppl. 28-29 39 PMID: 9589348

Sato et al (1994) Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells. Biochem.Biophys.Res.Commun. 204 578 PMID: 7980517

Keywords: Apigenin, supplier, Protein, kinase, inhibitors, inhibits, Kinases, Broad, Spectrum, Broad, Spectrum, Protein, Kinase, Inhibitors, IRE1, Broad, Spectrum, Protein, Kinase, Inhibitors, Tocris Bioscience

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