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Tocris/DL-TBOA/1223/10/10 mg

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货号: 1223/10

品牌: Tocris

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Description: Selective non-transportable inhibitor of EAATs

Chemical Name: DL-threo-β-Benzyloxyaspartic acid

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

A competitive, non-transportable blocker of excitatory amino acid transporters (IC₅₀ values are 70, 6, and 6 μM for EAAT1, EAAT2 and EAAT3 respectively). Also inhibits EAAT4 and EAAT5 (K_i values are 4.4 and 3.2 μM respectively). Displays high selectivity for EAATs over ionotropic and metabotropic glutamate receptors. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™.

Licensing Information

Sold for research purposes under license from Suntory Ltd.

Compound Libraries

DL-TBOA is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	239.23
Formula	C₁₁H₁₃NO₅
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	205309-81-5
PubChem ID	90479771
InChI Key	CSEZCYBVEGIYNG-MFBWXLJUSA-N
Smiles	[H][C@@](OCC1=CC=CC=C1)(C(O)=O)[C@@]([H])(C(O)=O)N.[H][C@](OCC2=CC=CC=C2)(C(O)=O)[C@]([H])(C(O)=O)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	23.92	100
	water	1.2	5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 239.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.18 mL	20.9 mL	41.8 mL
5 mM	0.84 mL	4.18 mL	8.36 mL
10 mM	0.42 mL	2.09 mL	4.18 mL
50 mM	0.08 mL	0.42 mL	0.84 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Jabaudon et al (1999) Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin. Proc.Natl.Acad.Sci.U.S.A. 96 8733 PMID: 10411944

Shigeri et al (2001) Effects of threo-β-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5). J.Neurochem. 79 297 PMID: 11677257

Shimamoto et al (1998) DL-threo-β-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters. Mol.Pharmacol. 53 195 PMID: 9463476

Shimamoto et al (2000) Syntheses of optically pure β-hydroxyaspartate derivatives as glutamate transporter blockers. Bioorg.Med.Chem.Lett. 10 2407 PMID: 11078189

Keywords: DL-TBOA, supplier, non-transportable, inhibitors, inhibits, EAATs, EAAT1, EAAT2, EAAT3, EAAT4, EAAT5, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, Glutamate, Transporters, Glutamate, Transporters, Tocris Bioscience

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