Chemical Name:N-[4-[1-(3-Aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl-1,3-propanediamine
Biological Activity
Technical Data
Solubility
Calculators
Datasheets
References
Biological Activity
A stable complex of nitric oxide and spermine used to generate a controlled release of nitric oxide in solution (EC50 = 6.2 μM for relaxation of rabbit aorta, and t½ =39 min at 37°C, pH 7.4, aqueous solution).
Licensing Information
Sold with the permission of the NIH, US Patent 5,155,137
Technical Data
M. Wt
262.35
Formula
C10H26N6O2
Storage
Desiccate at -20°C
CAS Number
136587-13-8
PubChem ID
5259
InChI Key
QPIOUFBAROSIAN-UHFFFAOYSA-N
Smiles
NCCCN(N(O)N=O)CCCCNCCCN
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent
Max Conc. mg/mL
Max Conc. mM
Solubility
water
26.23
100
Preparing Stock Solutions
The following data is based on the product molecular weight 262.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
1 mM
3.81 mL
19.06 mL
38.12 mL
5 mM
0.76 mL
3.81 mL
7.62 mL
10 mM
0.38 mL
1.91 mL
3.81 mL
50 mM
0.08 mL
0.38 mL
0.76 mL
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Product Datasheets
Certificate of Analysis / Product Datasheet
Safety Datasheet
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References
References are publications that support the products' biological activity.
Ferreroet al (1999) Comparative effects of several nitric oxide donors on intracellular cyclic GMP levels in bovine chromaffin cells: correlation with nitric oxide production. Br.J.Pharmacol. 127 779 PMID: 10401570
Homer and Wanstall
(1998) In vitro comparison of two NONOates (novel nitric oxide donors) on rat pulmonary arteries. Eur.J.Pharmacol. 356 49 PMID: 9761423
Maragoset al (1991) Complexes of NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J.Med.Chem. 34 3242 PMID: 1956043
Ramamurthi and Lewis
(1997) Measurement and modeling of nitric oxide release rates for nitric oxide donors. Chem.Res.Toxicol. 10 408 PMID: 9114977
Keywords: Spermine NONOate, supplier, Slow, NO, releasing, agent, ROS, Donors, Precursors, Nitric, Oxide, Signaling, Signalling, NO, Donors, /, Precursors, ROS, Donors, NO, Donors, /, Precursors, Tocris Bioscience
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