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Tocris/(<em>S</em>)-(+)-Niguldipine hydrochloride/1123/10/10 mg

Tocris/(S)-(+)-Niguldipine hydrochloride/1123/10/10 mg

价格: ¥2028.00 市场价: 3380.00

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货号: 1123/10

品牌: Tocris

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Description: α₁ antagonist, L-type Ca²⁺ channel blocker

Chemical Name: (S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-(4,4-diphenyl-1-piperidinyl)propyl methyl ester hydrochloride

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

L-type Ca²⁺ channel blocker and α_1A-adrenoceptor antagonist; more active enantiomer. (R)-(-)-Niguldipine hydrochloride (Cat. No. 1124) also available.

Compound Libraries

(S)-(+)-Niguldipine hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	646.18
Formula	C₃₆H₃₉N₃O₆.HCl
Storage	Desiccate at -20°C
CAS Number	113145-69-0
PubChem ID	6419995
InChI Key	JTQJFSQQHGPLOX-UHFFFAOYSA-N
Smiles	O=C(OC)C1=C(C)NC(C)=C(C(OCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3)=O)[C@H]1[C@]2=CC=CC([N+]([O-])=O)=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	64.62	100
	ethanol	64.62	100

Preparing Stock Solutions

The following data is based on the product molecular weight 646.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.55 mL	7.74 mL	15.48 mL
5 mM	0.31 mL	1.55 mL	3.1 mL
10 mM	0.15 mL	0.77 mL	1.55 mL
50 mM	0.03 mL	0.15 mL	0.31 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Boer et al (1989) (+)-Niguldipine binds with very high affinity to Ca²⁺ channels and to a subtype of alpha₁-adrenoceptor. Eur.J.Pharmacol. 172 131 PMID: 2548881

Graziadei et al (1989) Stereoselective binding of niguldipine enantiomers to alpha_1A-adrenoceptors labeled with [³H]5-methyl-urapidil. Eur.J.Pharmacol. 172 329 PMID: 2555206

Hollt et al (1992) Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein. Biochem.Pharmacol. 43 2601 PMID: 1352973

Wetzel et al (1995) Discovery of alpha_1a-adrenergic receptor antagonists based on the L-type Ca²⁺ channel antagonist niguldipine. J.Med.Chem. 38 1579 PMID: 7752182

Keywords: (S)-(+)-Niguldipine hydrochloride, supplier, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, a1-adrenergic, α1-adrenergic, alpha1-adrenergic, antagonists, L-type, Ca2+, channel, blockers, Receptors, Calcium, CaV, Channels, voltage-gated, voltage-dependent, Adrenergic, Alpha-1, Receptors, Voltage-gated, Calcium, Channels, Adrenergic, Alpha-1, Receptors, Tocris Bioscience

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