Insulin-like Growth Factor I, IGF-I, is a growth factor producedin response to growth hormone-stimulated liver and can be foundcirculating throughout the body and throughout life. IGF-Iactivates the IGF-I receptor (IGF1R) and the insulin receptor tomediate growth of almost every cell of the body. IGF-I is knownas one of the most potent activators of the AKT signaling pathwaywhich is known to be a stimulator of proliferation and aninhibitor of programmed cell death.Mature human IGF-I is 100%homologous with bovine and porcine proteins. Recombinantrat IGF-I is a non-glycosylated protein, containing 70 aminoacids and has a predicted molecular weight of 7.7 kDa.
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