Flt3-Ligand is a growth factor important for the proliferation ofhematopoietic cells. Flt3-Ligand binds to, and transmits signalsthrough, the receptor tyrosine kinase known as FMS-like TyrosineKinase-3 (FLT-3). Flt3 Ligand promotes long-term expansion anddifferentiation of human pro-B-cells in the presence of IL-7 orin combination of IL-7 and IL-3. Human Flt3-Ligand can stimulatethe proliferation of cells expressing murine FLT-3receptors.Recombinant mouse Flt3-Ligand is a non-glycosylatedprotein, containing 163 amino acids and having a molecular massof 18.6 kDa.
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