Description:Promotesassemblyandinhibitsdisassemblyofmicrotubules
AlternativeNames:Paclitaxel
ChemicalName:[2aR-[2aα,4β,4aβ,6α,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylesterbenzenepropanoicacid
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Antitumoragent;promotesandstABIlizestubulinpolymerization,causingcellcyclearrest.Inducesautocatalyticactivationofcaspase-10inCCRF-HSB-2cells,triggeringapoptosis.
CompoundLibraries
TaxolisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 853.92 |
| Formula | C47H51NO14 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 33069-62-4 |
| PubChemID | 441276 |
| InChIKey | RCINICONZNJXQF-VAZQATRQSA-N |
| Smiles | O=C2[C@@]3(C)C([C@@]4(OC(C)=O)[C@H](OC4)C[C@@H]3O)[C@H](OC(C7=CC=CC=C7)=O)[C@@]1(O)[C@](C)(C)C([C@H]2OC(C)=O)=C(C)[C@@H](OC([C@H](O)[C@H]([C@]5=CC=CC=C5)NC(C6=CC=CC=C6)=O)=O)C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
|---|
| Solubility |
|---|
| DMSO | 85.39 | 100mMwithgentlewarming |
| ethanol | 21.35 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight853.92.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 1.17mL | 5.86mL | 11.71mL |
| 5mM | 0.23mL | 1.17mL | 2.34mL |
| 10mM | 0.12mL | 0.59mL | 1.17mL |
| 50mM | 0.02mL | 0.12mL | 0.23mL |
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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