Chemical Name: (RS)-2-Chloro-5-hydroxyphenylglycine
Purity: ≥99% (HPLC)
Biological Activity
Technical Data
Solubility
Calculators
Datasheets
References
Biological Activity
A selective mGlu5 metabotropic glutamate receptor agonist, completely inactive at mGlu1a receptors expressed in CHO cells. Active in vivo. CHPG sodium salt (Cat. No. 3695) also available.
Technical Data
M. Wt
201.61
Formula
C8H8NO3Cl
Storage
Store at RT
Purity
≥99% (HPLC)
CAS Number
170846-74-9
PubChem ID
3645780
InChI Key
UNIDAFCQFPGYJJ-UHFFFAOYSA-N
Smiles
NC(C(O)=O)C1=CC(O)=CC=C1Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent
Max Conc. mg/mL
Max Conc. mM
Solubility
1.1eq. NaOH
20.16
100
Preparing Stock Solutions
The following data is based on the product molecular weight 201.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
1 mM
4.96 mL
24.8 mL
49.6 mL
5 mM
0.99 mL
4.96 mL
9.92 mL
10 mM
0.5 mL
2.48 mL
4.96 mL
50 mM
0.1 mL
0.5 mL
0.99 mL
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Product Datasheets
Certificate of Analysis / Product Datasheet
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References
References are publications that support the products' biological activity.
Baoet al (2001) Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischaemia. Brain Res. 922 173 PMID: 11743947
Dohertyet al (1997) (RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but not mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology 36 265 PMID: 9144665
Saltet al (1999) Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus. Br.J.Pharmacol. 127 1057 PMID: 10455248
Ugoliniet al (1999) Potentiation of NMDA and AMPA responses by the specific mGluR5 agonist CHPG in spinal cord motoneurones. Neuropharmacology 38 1569 PMID: 10530818
Keywords: CHPG, supplier, mGlu5, mGluR5, selective, agonist, mGlur, Group, I, Receptors, Glutamate, Metabotropic, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience
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