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Tocris/1-EBIO/1041/10/10 mg

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货号: 1041/10

品牌: Tocris

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Description: Activator of epithelial K_Ca channels

Chemical Name: 1-Ethyl-2-benzimidazolinone

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Activator of epithelial K_Ca channels, stimulates a large and sustained trans-epithelial Cl^- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes.

Compound Libraries

1-EBIO is also offered as part of the Tocriscreen Plus and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	162.19
Formula	C₉H₁₀N₂O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	10045-45-1
PubChem ID	82320
InChI Key	CXUCKELNYMZTRT-UHFFFAOYSA-N
Smiles	CCN1C(=O)NC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	tris buffer solution	5.35	33mM with gentle warming
	DMSO	16.22	100
	ethanol	16.22	100

Preparing Stock Solutions

The following data is based on the product molecular weight 162.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.17 mL	30.83 mL	61.66 mL
5 mM	1.23 mL	6.17 mL	12.33 mL
10 mM	0.62 mL	3.08 mL	6.17 mL
50 mM	0.12 mL	0.62 mL	1.23 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Ayotunde and Adeagbo (1999) 1-Ethyl-2-benzimidazolinone stimulates endothelial K_Ca channels and nitric oxide formation in rat mesenteric vessels. Eur.J.Pharmacol. 379 151 PMID: 10497901

Devor et al (1996) Modulation of Cl^- secretion by benzimidazolones. I. Direct activation of a Ca²⁺ - dependent K⁺ channel. Am.J.Physiol. 271 L775 PMID: 8944721

Kusama et al (2005) Reduced hyperpolarisation in endothelial cells of rabbit aortic value following chronic nitroglycerine administration. Br.J.Pharmacol. 146 487 PMID: 16056232

Kleger et al (2010) Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells. Circulation. 122 1823 PMID: 20956206

Keywords: 1-EBIO, supplier, Activator, epithelial, Kca, channels, Potassium, Channels, ca2+-activated, ca2+-dependent, K+, Ca2+-Activated, Potassium, Channels, Cardiomyocyte, Stem, Cells, ESCs, and, iPSC, Ca2+-Activated, Potassium, Channels, Tocris Bioscience

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