Chemical Name: 7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester
Purity: ≥99% (HPLC)
Biological Activity
Technical Data
Solubility
Calculators
Datasheets
References
Biological Activity
hmGlu1 subtype-selective non-competitive antagonist (IC50 = 6.5 μM). Has no agonist or antagonist activity at hmGlu2, 4a, 5a, 7b, 8a or ionotropic receptors at concentrations of up to 100 μM.
Licensing Information
Sold for research purposes under license from Suntory Ltd.
Compound Libraries
CPCCOEt is also offered as part of the
Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
M. Wt
247.25
Formula
C13H13NO4
Storage
Store at RT
Purity
≥99% (HPLC)
CAS Number
179067-99-3
PubChem ID
6278000
InChI Key
FXCTZFMSAHZQTR-KAMYIIQDSA-N
Smiles
O=C(OCC)C3(C2C3)OC1=CC=CC=C1/C2=N/O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent
Max Conc. mg/mL
Max Conc. mM
Solubility
DMSO
24.73
100
ethanol
1.24
5
Preparing Stock Solutions
The following data is based on the product molecular weight 247.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
1 mM
4.04 mL
20.22 mL
40.44 mL
5 mM
0.81 mL
4.04 mL
8.09 mL
10 mM
0.4 mL
2.02 mL
4.04 mL
50 mM
0.08 mL
0.4 mL
0.81 mL
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Product Datasheets
Certificate of Analysis / Product Datasheet
Safety Datasheet
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References
References are publications that support the products' biological activity.
Hermanset al (1998) Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1α metabotropic glutamate receptor. Neuropharmacology 37 1645 PMID: 9886688
Litschiget al (1999) CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding. Mol.Pharmacol. 55 453 PMID: 10051528
Annouraet al (1996) A novel class of antagonists for metabotropic glutamate receptors, 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylates. Bioorg.Med.Chem.Lett. 6 763 PMID:
Keywords: CPCCOEt, supplier, Selective, non-competitive, mGlu1, mGluR1, receptor, antagonists, Group, I, Receptors, Glutamate, Metabotropic, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience
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