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Tocris/ZD 7288/1000/50/50 mg

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货号: 1000/50

品牌: Tocris

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Description: Inhibits pacemaker (I_f) current

Alternative Names: ICI D7288

Chemical Name: 4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Sino-atrial node function modulator; blocks the hyperpolarization activated cation current I_f (HCN channel). Blocks I_h in central neurons. Increases NMDA-evoked noradrenalin release in rat brain in vitro.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries

ZD 7288 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	292.81
Formula	C₁₅H₂₁ClN₄
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	133059-99-1
PubChem ID	123983
InChI Key	DUWKUHWHTPRMAP-UHFFFAOYSA-N
Smiles	[Cl-].CCN(C1=CC=CC=C1)C1=CC(NC)=[N+](C)C(C)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.28	100
	water	29.28	100

Preparing Stock Solutions

The following data is based on the product molecular weight 292.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.42 mL	17.08 mL	34.15 mL
5 mM	0.68 mL	3.42 mL	6.83 mL
10 mM	0.34 mL	1.71 mL	3.42 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

BoSmith et al (1993) Inhibitory actions of ZENECA ZD7288 on whole cell hyperpolarization activated inward current (I_f) in guinea-pig dissociated sinoatrial node cells. Br.J.Pharmacol. 110 343 PMID: 7693281

Green et al (1996) Pharmacological characterization of the inwardly rectifying current in the smooth muscle cells of the rat bladder. Br.J.Pharmacol. 119 1509 PMID: 8982495

Harris and Constanti (1995) Mechanism of block by ZD7288 of the hyperpolarization-activated inward rectifying current in guinea-pig substantia nigra neurons in vitro. J.Neurophysiol. 74 2366 PMID: 8747199

Klar et al (2003) Ih channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [³H]-noradrenaline release in rat neocortex slices. Naunyn Schmiedebergs Arch.Pharmacol. 367 422 PMID: 12690435

Keywords: ZD 7288, supplier, Sino-atrial, node, function, modulators, If, inhibitors, inhibits, Channel, VDAC, ZD7288, ICID7288, AstraZeneca, HCN, ICI, D7288, HCN, Channels, HCN, Channels, Tocris Bioscience

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