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Tocris/RS 17053 hydrochloride/0985/50/50 mg

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货号: 0985/50

品牌: Tocris

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Description: α_1A antagonist

Chemical Name: (N-[2-(2-Cyclopropylmethoxyphenoxy)ethyl]-5-chloro-α,α-dimethyl-1H-indole-3-ethanamine) hydrochloride

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

α_1A-adrenoceptor antagonist, with very high affinity for α_1A receptors (pK_i and pA₂ estimates of 9.1 - 9.9) and a 30 - 100 fold selectivity over the α_1B and α_1D subtypes (pK_i and pA₂ estimates 7.7 - 7.8).

Licensing Information

Sold with the permission of Roche Bioscience

Compound Libraries

RS 17053 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	449.42
Formula	C₂₄H₂₉N₂O₂Cl.HCl
Storage	Store at RT
CAS Number	169505-93-5
PubChem ID	9824953
InChI Key	QFOPFGRPNPCPBX-UHFFFAOYSA-N
Smiles	Cl.CC(C)(CC1=CNC2=CC=C(Cl)C=C12)NCCOC1=C(OCC2CC2)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	22.47	50
	ethanol	4.49	10

Preparing Stock Solutions

The following data is based on the product molecular weight 449.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.23 mL	11.13 mL	22.25 mL
5 mM	0.45 mL	2.23 mL	4.45 mL
10 mM	0.22 mL	1.11 mL	2.23 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Ford et al (1996) RS 17053 (N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-α,α-dimethyl-1H-indole-3-ethanamine hydrochloride, a selective α_1A-adrenoceptor antagonist, displays low affinity for functional α₁-adrenoceptors in huma Mol.Pharmacol. 49 209 PMID: 8632751

Marshall et al (1996) Different subtypes of α_1A-adrenoceptor mediating contraction of rat epididymal vas deferens, rat hepatic portal vein and human prostate distinguished by the antagonist RS 17053. Br.J.Pharmacol. 119 407 PMID: 8886428

Ford et al (1995) Do α_1A (α_1C)-adrenoceptors (AR) mediate prostatic smooth muscle contraction in man? Studies with a novel, selective α_1A-AR antagonist, RS 17053. Br.J.Pharmacol. 114 C25 PMID:

Keywords: RS 17053 hydrochloride, supplier, α1A-adrenoceptor, alpha1A-adrenoceptor, α1-adrenergic, alpha1-adrenergic, a1-adrenoceptor, a1-adrenergic, antagonists, receptors, RS17053, hydrochloride, Adrenergic, Alpha-1, Receptors, Adrenergic, Alpha-1, Receptors, Tocris Bioscience

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