Description: Selective, competitive, orally active GABAB antagonist
Chemical Name: (2S)-(+)-5,5-Dimethyl-2-morpholineacetic acid
Purity: ≥98%
Biological Activity
Technical Data
Solubility
Calculators
Datasheets
References
Biological Activity
A selective, competitive and orally active GABAB antagonist. Displays an IC50 of 1.1 μM at GABAB, approximately 60 times that of CGP 35348 (Cat. No. 1245) and no binding affinity for GABAA at concentrations up to 100 μM.
Licensing Information
Sold with the permission of Schering Plough Corporation
Technical Data
M. Wt
173.21
Formula
C8H15NO3
Storage
Desiccate at -20°C
Purity
≥98%
CAS Number
733717-87-8
PubChem ID
5311429
InChI Key
SEYCKMQSPUVYEF-LURJTMIESA-N
Smiles
[H][C@]1(CC(O)=O)CNC(C)(C)CO1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent
Max Conc. mg/mL
Max Conc. mM
Solubility
phosphate buffered saline
17.32
100
water
17.32
100
Preparing Stock Solutions
The following data is based on the product molecular weight 173.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
1 mM
5.77 mL
28.87 mL
57.73 mL
5 mM
1.15 mL
5.77 mL
11.55 mL
10 mM
0.58 mL
2.89 mL
5.77 mL
50 mM
0.12 mL
0.58 mL
1.15 mL
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Product Datasheets
Certificate of Analysis / Product Datasheet
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References
References are publications that support the products' biological activity.
Bolseret al (1995) The pharmacology of SCH 50911: a novel, orally active GABA-B receptor antagonist. J.Pharmacol.Exp.Ther. 274 1393 PMID: 7562513
Hosfordet al (1995) Characterization of the antiabsence effects of SCH 50911, a GABAB receptor antagonist, in the lethargic mouse, γ-hydroxybutyrate, and pentylenetetrazole models. J.Pharmacol. Exp.Ther. 274 1399 PMID: 7562514
Onget al (1998) The morpholino-acetic acid analogue Sch 50911 is a selective GABAB receptor antagonist in rat neocortical slices. Eur.J.Pharmacol. 362 35 PMID: 9865527
Blythinet al (1996) Substituted morpholine-2S-acetic acid derivatives: SCH 50911 and related compounds as novel GABAB antagonists. Bioorg.Med.Chem.Lett. 6 1529 PMID:
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