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Tocris/CPPG/0972/50/50 mg

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货号: 0972/50

品牌: Tocris

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Description: Potent group III mGlu antagonist

Chemical Name: (RS)-α-Cyclopropyl-4-phosphonophenylglycine

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent group II/III mGlu receptor antagonist, with approximately 20-fold selectivity for group III over group II (IC₅₀ values of 2.2 and 46.2 nM respectively). A much less potent antagonist at group I receptors in neonatal rat cortical slices (K_B = 0.65 ± 0.07 nM). Also available as part of the Group III mGlu Receptor Tocriset™.

Technical Data

M. Wt	271.21
Formula	C₁₁H₁₄NO₅P
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	183364-82-1
PubChem ID	2878
InChI Key	IGODGTDUQSMDQU-UHFFFAOYSA-N
Smiles	NC(C2CC2)(C(O)=O)C1=CC=C(P(O)(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH	27.12	100

Preparing Stock Solutions

The following data is based on the product molecular weight 271.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.69 mL	18.44 mL	36.87 mL
5 mM	0.74 mL	3.69 mL	7.37 mL
10 mM	0.37 mL	1.84 mL	3.69 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Jane et al (1996) Potent antagonists at the L-AP4- and (1S, 3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord. Neuropharmacology 35 1029 PMID: 9121605

Toms et al (1996) The effects of (RS)-α-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist. BrJ.Pharmacol. 119 851 PMID: 8922731

Kemp et al (1996) α-Methyl-3-phosphonophenylglycine and α-cyclopropyl-4-phosphonophenylglycine are potent antagonists at mGluRs negatively coupled to adenylyl cyclase. Br.J.Pharmacol. 117 (in press) PMID:

Keywords: CPPG, supplier, potent, group, III, Antagonists, Group, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGlu4R, mGlu6R, mGlu7R, mGlu8R, Glutamate, Metabotropic, Glutamate, (Metabotropic), Group, III, Receptors, Glutamate, (Metabotropic), Group, III, Receptors, Tocris Bioscience

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