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Tocris/Diazoxide/0964/100/100 mg

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货号: 0964/100

品牌: Tocris

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Description: Blocks desensitization of AMPA receptors

Chemical Name: 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Antihypertensive, activates ATP-dependent K⁺ channels (K_ir6). Induces activation of PKCε, an intermediate in the opening of mitoK_ATP channels, results in cardioprotection against hypoxia-induced death. Blocks desensitization of AMPA receptors.

Compound Libraries

Diazoxide is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	230.67
Formula	C₈H₇ClN₂O₂S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	364-98-7
PubChem ID	3019
InChI Key	GDLBFKVLRPITMI-UHFFFAOYSA-N
Smiles	CC1=NC2=C(C=C(Cl)C=C2)S(=O)(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	23.07	100

Preparing Stock Solutions

The following data is based on the product molecular weight 230.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.34 mL	21.68 mL	43.35 mL
5 mM	0.87 mL	4.34 mL	8.67 mL
10 mM	0.43 mL	2.17 mL	4.34 mL
50 mM	0.09 mL	0.43 mL	0.87 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Kim et al (2006) Diazoxide acts more as a PKC-ε activator, and indirectly activates the mitochondiral K_ATP channel conferring cardioprotection against hypoxic injury. Br.J.Pharmacol. 149 1059 PMID: 17043673

Trube et al (1986) Opposite effects of tolbutamide and diazoxide on the ATP-dependent K⁺ channel in mouse pancreatic β-cells. Pflugers Arch. 407 493 PMID: 2431383

Yamada and Rothman (1992) Diazoxide blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons. J.Physiol. 458 409 PMID: 1302270

Merck Index 12 3051 PMID:

Keywords: Diazoxide, supplier, Blocks, desensitization, desensitisation, AMPA, receptors, K+, channel, opener, KATP, Glutamate, Receptors, iGlur, Ionotropic, Potassium, KIR, Kir6, Channels, Inward, Rectifier, AMPA, Receptors, Inward, rectifier, Potassium, Channels, AMPA, Receptors, Tocris Bioscience

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