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Tocris/SCH 23390 hydrochloride/0925/10/10 mg

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货号: 0925/10

品牌: Tocris

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Description: Standard selective D₁-like antagonist; also 5-HT_2C and 5-HT_1C agonist and K_ir3 channel blocker

Alternative Names: (R)-(+)-SCH 23390 hydrochloride

Chemical Name: (R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent dopamine receptor antagonist (K_i values are 0.2 nM and 0.3 nM at D₁ and D₅ receptor sub-types, respectively). Also an agonist at 5-HT_1C and 5-HT_2C receptors in vitro (K_i values are 6.3 nM and 9.3 nM respectively). Blocks quinpirole-induced K_ir3 (GIRK) currents (EC₅₀ = 268 nM) independently of receptors.

Technical Data

M. Wt	324.24
Formula	C₁₇H₁₈ClNO.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	125941-87-9
PubChem ID	11957535
InChI Key	OYCAEWMSOPMASE-XFULWGLBSA-N
Smiles	ClC1=C(O)C=C([C@](C3=CC=CC=C3)([H])C2)C(CCN2C)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	32.42	100
	ethanol	16.21	50
	water	32.42	100mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 324.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.08 mL	15.42 mL	30.84 mL
5 mM	0.62 mL	3.08 mL	6.17 mL
10 mM	0.31 mL	1.54 mL	3.08 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Bourne et al (2001) SCH 23390: The first selective dopamine D₁-like receptor antagonist. CNS Drug Rev. 7 399 PMID: 11830757

Briggs et al (1991) Activation of the 5-HT_1C receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393. Br.J.Pharmacol. 104 1038 PMID: 1687364

Millan et al (2001) The "selective" dopamine D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist against cloned human serotonin_2C receptors. Psychopharmacology 156 58 PMID: 11465634

Kuzhikandathil and Oxford (2002) Classic D₁ dopamine receptor antagonist R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) directly inhibits G protein-coupled inwardly rectifying potassium channels. Mol.Pharmacol. 62 119 PMID: 12065762

Keywords: SCH 23390 hydrochloride, supplier, 5-HT2C, agonists, potent, D1-like, antagonists, selective, Serotonin, Receptors, Dopamine, D1, D5, dopaminergic, SCH23390, hydrochloride, (R)-(+)-SCH, 23390, hydrochloride, D1, and, D5, Receptors, 5-HT2C, Receptors, Inward, rectifier, Potassium, Channels, D1, and, D5, Receptors, Tocris Bioscience

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