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Tocris/SYM 2081/0903/50/50 mg

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货号: 0903/50

品牌: Tocris

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Description: Highly selective kainate agonist

Chemical Name: (2S,4R)-4-Methylglutamic acid

Purity: ≥97% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent and highly selective kainate receptor agonist, with an IC₅₀ for inhibition of [³H]-kainate binding of 35 nM and almost 3,000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively. Also selectively inhibits the cloned excitatory amino acid transporter EAAT2 at higher concentrations. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™ and Kainate Receptor Tocriset™.

Licensing Information

Sold with the permission of Annovis Inc.

Technical Data

M. Wt	161.16
Formula	C₆H₁₁NO₄
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	31137-74-3
PubChem ID	95883
InChI Key	KRKRAOXTGDJWNI-DMTCNVIQSA-N
Smiles	[H][C@@](N)(C(O)=O)C[C@]([H])([C@](O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	phosphate buffered saline	8.06	50
	1eq. NaOH	16.12	100
	water	8.06	50

Preparing Stock Solutions

The following data is based on the product molecular weight 161.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.21 mL	31.03 mL	62.05 mL
5 mM	1.24 mL	6.21 mL	12.41 mL
10 mM	0.62 mL	3.1 mL	6.21 mL
50 mM	0.12 mL	0.62 mL	1.24 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Donevan et al (1998) The methylglutamate, SYM 2081, is a potent and highly selective agonist at kainate receptors. J.Pharmacol.Exp.Ther. 285 539 PMID: 9580595

Jones et al (1997) Desensitization of kainate receptors by kainate, glutamate and diastereomers of 4-methylglutamate. Neuropharmacology 36 853 PMID: 9225313

Savidge et al (1999) Characterisation of kainate receptor mediated whole-cell currents in rat cultured cerebellar granule cells. Neuropharmacology 38 375 PMID: 10219975

Zhou et al (1997) (2S,4R)-4-Methylglutamic acid (SYM 2081): a selective, high affinity ligand for kainate receptors. J.Pharmacol.Exp.Ther. 280 422 PMID: 8996224

Keywords: SYM 2081, supplier, inhibitors, inhibits, EAAT2, kainate, receptors, agonist, selective, EAAT, Excitatory, Amino, Acid, Transporters, GLT-1, Glutamate, Monoamine, Neurotransmitter, iGluR, Ionotropic, SYM2081, Glutamate, Transporters, Kainate, Receptors, Kainate, Receptors, Tocris Bioscience

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