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Tocris/Rauwolscine hydrochloride/0891/100/100 mg

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货号: 0891/100

品牌: Tocris

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Description: α₂ antagonist

Alternative Names: α-Yohimbine hydrochloride, Corynanthidine

Chemical Name: 17α-Hydroxy-20α-yohimban-16β-carboxylic acid,methyl ester hydrochloride

Purity: ≥95% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Standard α₂-adrenergic antagonist (K_i values are 3.5, 4.6, and 0.6 nM at cloned human α_2A, α_2B, and α_2C-adrenoceptors respectively). Partial agonist at 5-HT_1A receptors. Also available as part of the α₂-Adrenoceptor Tocriset™. Diastereomer Yohimbine hydrochloride (Cat. No. 1127) also available.

Compound Libraries

Rauwolscine hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	390.91
Formula	C₂₁H₂₆N₂O₃.HCl
Storage	Store at RT
Purity	≥95% (HPLC)
CAS Number	6211-32-1
PubChem ID	197067
InChI Key	PIPZGJSEDRMUAW-ZKKXXTDSSA-N
Smiles	[H][C@]12C4=C(C(C=CC=C5)=C5N4)CCN1C[C@]3([H])[C@]([C@H]([C@](OC)=O)[C@@H](O)CC3)([H])C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	9.77	25mM with gentle warming
	ethanol		5
	water		5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 390.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.56 mL	12.79 mL	25.58 mL
5 mM	0.51 mL	2.56 mL	5.12 mL
10 mM	0.26 mL	1.28 mL	2.56 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Arthur et al (1993) Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT_1A receptors. Biochem.Pharmacol. 45 2337 PMID: 8517875

Hieble et al (1995) β- and γ-Adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 38 3415 PMID: 7658428

Uhlen et al (1998) [3H]RS79948-197 binding to human, rat, guinea pig and pig α_2A-, α_2B-, and α_2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine. Eur.J.Pharmacol. 343 93 PMID: 9551719

Keywords: Rauwolscine hydrochloride, supplier, α2-adrenoceptor, alpha2-adrenoceptor, antagonists, α2-Adrenergic, alpha2-Adrenergic, a2-adrenoceptor, a2-adrenergic, Receptors, alpha-Yohimbine, hydrochloride, a-Yohimbine, hydrochloride, Corynanthidine, Adrenergic, Alpha-2, Receptors, Adrenergic, Alpha-2, Receptors, Tocris Bioscience

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