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Tocris/MPPG/0853/10/10 mg

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货号: 0853/10

品牌: Tocris

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Description: Group III/group II mGlu antagonist. More selective for group III than group II

Chemical Name: (RS)-α-Methyl-4-phosphonophenylglycine

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent antagonist of L-AP4-induced effects in rat spinal cord, thalamic and hippocampal neurons, showing selectivity over (1S,3S)-ACPD-induced effects. Potent antagonist of mGlu receptors linked to adenylyl cyclase in adult rat cortical slices.

Technical Data

M. Wt	245.17
Formula	C₉H₁₂NO₅P
Storage	Store at RT
CAS Number	169209-65-8
PubChem ID	3972752
InChI Key	PAONCRJPUQXPRW-UHFFFAOYSA-N
Smiles	NC(C(O)=O)(C)C1=CC=C(P(O)(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility	Soluble to 100 mM in 1eq. NaOH

Solubility

Soluble to 100 mM in 1eq. NaOH

Preparing Stock Solutions

The following data is based on the product molecular weight 245.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.08 mL	20.39 mL	40.79 mL
5 mM	0.82 mL	4.08 mL	8.16 mL
10 mM	0.41 mL	2.04 mL	4.08 mL
50 mM	0.08 mL	0.41 mL	0.82 mL

Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service

Safety Datasheet

References

References are publications that support the products' biological activity.

Bedingfield et al (1996) Novel potent selective phenylglycine antagonists of metabotropic glutamate receptors. Eur.J.Pharmacol. 309 71 PMID: 8864696

Bushell et al (1996) Pharmacological antagonism of the actions of group II and group III mGluR agonists in the lateral perforant path of rat hippocampal slices. Br.J.Pharmacol. 117 1457 PMID: 8730739

Jane et al (1995) New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord. Neuropharmacology 34 851 PMID: 8532166

Salt and Turner (1996) Antagonism of the presumed presynaptic action of L-AP4 on GABAergic transmission in the ventrobasal thalamus by the novel mGluR anatagonist MPPG. Neuropharmacology 35 239 PMID: 8734494

Keywords: MPPG, supplier, Group, III, group, II, mGlur, antagonists, selective, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGluR4, mGluR6, mGluR7, mGluR8, Glutamate, Metabotropic, Glutamate, (Metabotropic), Group, III, Receptors, Glutamate, (Metabotropic), Group, III, Receptors, Tocris Bioscience

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