Description: Selective group I mGlu agonist. Active enantiomer of 3,5-DHPG (Cat. No. 0342)
Chemical Name: (S)-3,5-Dihydroxyphenylglycine
Purity: ≥98% (HPLC)
Biological Activity
Technical Data
Solubility
Calculators
Datasheets
References
Biological Activity
Selective group I mGlu receptor agonist. Also available as part of the Group I mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™. (RS)-3,5-DHPG (Cat. No. 0342) also available.
Technical Data
M. Wt
183.16
Formula
C8H9NO4
Storage
Desiccate at -20°C
Purity
≥98% (HPLC)
CAS Number
162870-29-3
PubChem ID
443586
InChI Key
HOOWCUZPEFNHDT-ZETCQYMHSA-N
Smiles
OC1=CC([C@]([H])(N)C(O)=O)=CC(O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent
Max Conc. mg/mL
Max Conc. mM
Solubility
phosphate buffered saline
9.16
50
DMSO
3.66
20mM with gentle warming
water
9.16
50
Preparing Stock Solutions
The following data is based on the product molecular weight 183.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
1 mM
5.46 mL
27.3 mL
54.6 mL
5 mM
1.09 mL
5.46 mL
10.92 mL
10 mM
0.55 mL
2.73 mL
5.46 mL
50 mM
0.11 mL
0.55 mL
1.09 mL
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Product Datasheets
Certificate of Analysis / Product Datasheet
Safety Datasheet
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References
References are publications that support the products' biological activity.
Schoeppet al (1994) 3,5-Dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus. J.Neurochem. 63 769 PMID: 8035201
Sekiyamaet al (1996) Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 117 1493 PMID: 8730745
Wisniewski and Car
(2002) (S)-3,5-DHPG: a review. CNS Drug Rev. 8 101 PMID: 12070529
Bakeret al (1995) Enzymatic resolution and pharmacological activity of the enantiomers of 3,5-dihydroxyphenylglycine, a metabotropic glutamate receptor agonist. Bioorg.Med.Chem.Lett. 5 223 PMID:
Keywords: (S)-3,5-DHPG, supplier, Selective, group, I, agonists, Active, enantiomer, Group, Receptors, mGlu1, mGlu5, mGluR1, mGluR5, Glutamate, Metabotropic, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience
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