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Tocris/MSOP/0803/10/10 mg

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货号: 0803/10

品牌: Tocris

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Description: Specific group III mGlu antagonist

Chemical Name: (RS)-α-Methylserine-O-phosphate

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective group III metabotropic glutamate receptor antagonist. Displays an apparent K_D of 51 μM for the L-AP4-sensitive presynaptic mGluR on primary afferent terminals in spinal cord compared to > 700 μM for the (1S,3S)-ACPD-sensitive presynaptic mGlu in the same system. Has no activity on postsynaptic mGlu receptors or on ionotropic glutamate receptors on neonatal rat motoneurons. Also available as part of the Group III mGlu Receptor Tocriset™.

Technical Data

M. Wt	199.1
Formula	C₄H₁₀NO₆P
Storage	Store at RT
CAS Number	66515-29-5
PubChem ID	3964633
InChI Key	GSFCOAGADOGIGE-UHFFFAOYSA-N
Smiles	NC(COP(O)(O)=O)(C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	19.91	100

Preparing Stock Solutions

The following data is based on the product molecular weight 199.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.02 mL	25.11 mL	50.23 mL
5 mM	1 mL	5.02 mL	10.05 mL
10 mM	0.5 mL	2.51 mL	5.02 mL
50 mM	0.1 mL	0.5 mL	1 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Thomas et al (1996) α-Methyl derivatives of serine-O-phosphate as novel, selective competitive metabotropic glutamate receptor antagonists. Neuropharmacology 35 637 PMID: 8887973

Jane et al (1996) Phosphono substituted amino acids as selective metabotropic glutamate receptor antagonists. Phosphorous, Sulphur and Silicon 109-110 313 PMID:

Thomas et al (1995) Serine-O-phosphate derivatives as novel, potent and selective metabotropic glutamate receptor (mGluR) antagonists. Soc.Neurosci.Abstr. 21 P616 PMID:

Keywords: MSOP, supplier, Specific, group, III, mGlur, antagonists, Group, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGluR4, mGluR6, mGluR7, mGluR8, Glutamate, Metabotropic, Glutamate, (Metabotropic), Group, III, Receptors, Glutamate, (Metabotropic), Group, III, Receptors, Tocris Bioscience

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