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Tocris/SIN-1 chloride/0756/50/50 mg

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货号: 0756/50

品牌: Tocris

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Description: Water-soluble NO donor

Alternative Names: 3-Morpholinylsydnoneimine chloride

Chemical Name: Amino-3-morpholinyl-1,2,3-oxadiazolium chloride

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

This compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.

Technical Data

M. Wt	206.63
Formula	C₆H₁₁ClN₄O₂
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	16142-27-1
PubChem ID	197942
InChI Key	ZRFWHHCXSSACAW-UHFFFAOYSA-M
Smiles	NC1=C[N+](N2CCOCC2)=NO1.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	20.66	100
	water	20.66	100

Preparing Stock Solutions

The following data is based on the product molecular weight 206.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.84 mL	24.2 mL	48.4 mL
5 mM	0.97 mL	4.84 mL	9.68 mL
10 mM	0.48 mL	2.42 mL	4.84 mL
50 mM	0.1 mL	0.48 mL	0.97 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Maurice and Heslam (1990) Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Mol.Pharmacol. 37 671 PMID: 2160060

Nishikawa et al (1982) Inhibition of platelet aggregation and stimulation of guanylate cyclase by an anti-anginal agent molsidomine and its metabolite. J.Pharmacol.Exp.Ther. 220 183 PMID: 6118429

Siegfried et al (1992) Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ichemia-reperfusion. J.Pharmacol.Exp.Ther. 260 668 PMID: 1738117

Tanayama et al (1974) Biotransformation of molsidomine (SIN-10), a new anti-anginal agent in rats. Xenobiotica 4 175 PMID:

Keywords: SIN-1 chloride, supplier, Water-soluble, NO, donor, Guanylyl, cyclases, activators, ROS, Donors, sGC, Precursors, Nitric, Oxide, Signaling, Signalling, vasodilator, 3-Morpholinylsydnoneimine, chloride, NO, Donors, /, Precursors, Guanylyl, Cyclase, ROS, Donors, NO, Donors, /, Precursors, Tocris Bioscience

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