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Millipore/07-947 | Anti-dimethyl-Histone H4 (Arg3) Symmetric Antibody/07-947/100 µg
  • Millipore/07-947 | Anti-dimethyl-Histone H4 (Arg3) Symmetric Antibody/07-947/100 µg

Millipore/07-947 | Anti-dimethyl-Histone H4 (Arg3) Symmetric Antibody/07-947/100 µg

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货号: 07-947
品牌: Millipore
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    • Description
      CatalogueNumber07-947
      DescriptionAnti-dimethyl-HistoneH4(Arg3)SymmetricAntibody
      AlternateNames
      • histone4,H4
      • histoneH4
      • histonecluster4,H4
      BackgroundInformationHistonesarehighlyconservedproteinsthatserveasthestructuralscaffoldfortheorganizationofnuclearDNAintochromatin.Thefourcorehistones,H2A,H2B,H3,andH4,assembleintoanoctamer(2moleculesofeach).Histonesaremodifiedpost-translationallybytheactionsofenzymesinboththenucleusandcytoplasm.Thesemodifications,whichincludeacetylation,phosphorylation,methylation,andubiquitin-ation,occurpredominantlyontheN-terminalandC-terminaltailsthatextendbeyondthenucleosomecoreparticle.Argininemodificationsofhistonesproteinsaremediatedbytwoclassesofproteinargininemethyltransferases(PRMTs),classIandII.ClassIPRMTsplacetwomethylgroupsontheonenitrogenatomofthearginineguanidinogroup,resultinginanasymmetricmodification.IncontrastclassIIPRMTsplacetwomethylgroupsontwonitrogenatomsoftheguanidinogroupproducingasymmetricdimethylation.Althoughthereareexceptions,asymmetricmodificationsaretypicallyassociatedwithtranscriptionactivationwhilesymmetricmodificationsaremostcommonlyassociatedwithtranscriptionalrepression.
      ProductInformation
      FormatAffinityPurified
      Control
      • HeLaacidextract
      PresentationPurifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationUseAnti-dimethyl-HistoneH4(Arg3)SymmetricAntibody(rabbitpolyclonalantibody)validatedinWB,ICC,DBtodetectdimethyl-HistoneH4(Arg3)SymmetricalsoknownashistoneH4,histonecluster4H4.
      KeyApplications
      • WesternBlotting
      • Immunocytochemistry
      • DotBlot
      ApplicationNotesImmunocytochemistryAnalysis:1:500dilutionfromarepresentativelotdetectedHistoneH4inHeLaandA431cells.

      PeptideDotBlotAnalysis:0.5µg/mLofthisantibodydetectedHistoneH4dimethylArg3(symmetric)peptides,butdidnotdetectHistoneH4dimethylArg3(assymmetric)peptide,othermodifiedpeptides,ornon-methyatedhistoneH4peptides.
      BIOLOGicalInformation
      ImmunogenKLH-conjugatedlinearpeptidecorrespondingtohumanHistoneH4whensymmetricallydimethylatedatArg3.
      EpitopeSymmetricallydimethylatedArg3
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityThisantibodyrecognizesHistoneH4symmetricallydimethylatedatArg3.
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      SpeciesReactivityNoteDemonstratedtoreactwithhuman,mouse,andrat.Broadspeciescross-reactivityexpectedbasedonsequencesimilarity.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryHistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Thisstructureconsistsofapproximately146bpofDNAwrappedaroundanucleosome,anoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.ThisgeneisintronlessandencodesamemberofthehistoneH4family.TranscriptsfromthisgenelackpolyAtails;instead,theycontainapalindromicterminationelement.Thisgeneisfoundinahistoneclusteronchromosome1.Thisgeneisoneoffourhistonegenesintheclusterthatareduplicated;thisrecordrepresentsthetelomericcopy.[providedbyRefSeq].
      GeneSymbol
      • HIST1H4A
      • H4/J
      • HIST1H4F
      • HIST1H4L
      • H4FN
      • H4FA
      • H4FH
      • HIST1H4H
      • H4F2
      • H4FM
      • H4/A
      • H4FK
      • H4FG
      • HIST2H4
      • H4FB
      • H4/K
      • HIST1H4I
      • H4/N
      • HIST1H4B
      • H4FE
      • H4/M
      • H4/a
      • HIST1H4E
      • HIST4H4
      • HIST2H4A
      • H4FC
      • H4FI
      • H4/H
      • HIST1H4C
      • H4/G
      • HIST1H4K
      • H4FJ
      • H4FD
      • H4/I
      • H4/B
      • H4/D
      • H4/C
      • HIST1H4J
      • HIST1H4D
      • H4/E
      Modifications
      • Methylation
      PurificationMethodAffinityPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.

      SUBUNITSTRUCTURE:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.

      SUBCELLULARLOCATION:Nucleus.Chromosome.

      PTM:AcetylationatLys-6(H4K5ac),Lys-9(H4K8ac),Lys-13(H4K12ac)andLys-17(H4K16ac)occursincodingregionsofthegenomebutnotinheterochromatin.

      CitrullinationatArg-4(H4R3ci)byPADI4impairsmethylation.

      MonomethylationatArg-4(H4R3me1)byPRMT1favorsacetylationatLys-9(H4K8ac)andLys-13(H4K12ac).DemethylationisperformedbyJMJD6.

      SymmetricdimethylationonArg-4(H4R3me2a)bythePRDM1/PRMT5complexmayplayacrucialroleinthegerm-celllineage.

      Monomethylated,dimethylatedortrimethylatedatLys-21(H4K20me1,H4K20me2,H4K20me3).MonomethylationisperformedbySET8.TrimethylationisperformedbySUV420H1andSUV420H2andinducesgenesilencing.

      UbiquitinatedbytheCUL4-DDB-RBX1complexinresponsetoultravioletirradiation.ThismayweakentheinteractionbetweenhistonesandDNAandfacilitateDNAaccessibilitytorepairproteins.MonoubiquitinatedatLys-92ofhistoneH4(H4K91ub1)inresponsetoDNAdamage.TheexactroleofH4K91ub1inDNAdamageresponseisstillunclearbutitmayfunctionasalicensingsignalforadditionalhistoneH4post-translationalmodificationssuchasH4Lys-21methylation(H4K20me).

      Sumoylated,whichisassociatedwithtranscriptionalrepression.

      SEQUENCESIMILARITIES:BelongstothehistoneH4family.

      SEQUENCECAUTION:ThesequenceAAI28106.1differsfromthatshown.Reason:Frameshiftatposition3.
      MolecularWeight~13kDaobserved.Crossreactingbandat~58kDahasbeenobservedinsomelysates.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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