UniProtSummary | FUNCTION:ResponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).Histonedeacetylationgivesatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.InvolvedinmusclematurationbyrepressingtranscriptionofmyocyteenhancerfactorssuchasMEF2A,MEF2BandMEF2C.Duringmuscledifferentiation,itshuttlesintothecytoplasm,allowingtheexpressionofmyocyteenhancerfactorsBysimilarity.MaybeinvolvedinEpstein-Barrvirus(EBV)latency,possiblybyrepressingtheviralBZLF1gene.
CatalyticactivityHydrolysisofanN(6)-acetyl-lysineresidueofahistonetoyieldadeacetylatedhistone.
SUBUNIT:InteractswithHDAC1,HDAC2,HDAC3,HDAC4,HDAC5,NCOR1,NCOR2,SIN3A,SIN3B,RBBP4,RBBP7,MTA1L1,SAP30andMBD3.Interactswiththe14-3-3proteinYWHAE,MEF2A,MEF2BandMEF2CBysimilarity.InteractswithHTATIPandEDNRA.InteractswithJARID1B.
SUBCELLULARLOCATION:Nucleus.Cytoplasm.Note=Inthenucleus,itassociateswithdistinctsubnucleardot-likestructures.Shuttlesbetweenthenucleusandthecytoplasm.TreatmentwithEDN1resultsinshuttlingfromthenucleustotheperinuclearregion.Theexporttocytoplasmdependsontheinteractionwiththe14-3-3proteinYWHAEandmaybeduetoitsphosphorylation.
DOMAIN:ThenuclearexportsequencemediatestheshuttlingbetweenthenucleusandthecytoplasmBysimilarity.
PTM:MaybephosphorylatedbyCaMK1Bysimilarity.
MISCELLANEOUS:ItsactivityisinhibitedbyTrichostatinA(TSA),aknownhistonedeacetylaseinhibitorBysimilarity.
SIMILARITY:Belongstothehistonedeacetylasefamily.Type2subfamily.
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