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Millipore/07-606 | Anti-phospho-JAK2 (Tyr1007/1008) Antibody/07-606/200 µg
  • Millipore/07-606 | Anti-phospho-JAK2 (Tyr1007/1008) Antibody/07-606/200 µg

Millipore/07-606 | Anti-phospho-JAK2 (Tyr1007/1008) Antibody/07-606/200 µg

价格: ¥4068.00 市场价: 6780.00
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货号: 07-606
品牌: Millipore
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    • Description
      CatalogueNumber07-606
      Replaces04-1098
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-phospho-JAK2(Tyr1007/1008)Antibody
      AlternateNames
      • Januskinase2
      • Januskinase2(aproteintyrosinekinase)
      • tyrosine-proteinkinaseJAK2
      BackgroundInformationJAK2(JanusKinase2)belongstotheemergingfamilyofnon-receptorJanustyrosinekinases,whichregulateaspectrumofcellularfunctionsdownstreamofactivatedcytokinereceptorsinthelympho-hematopoieticsystem.Immunologicalstimuli,suchasinterferonsandcytokines,inducerecruitmentofStattranscriptionfactorstocytokinereceptor-associatedJAK2.JAK2thenphosphorylatesproximalStatfactors,whichsubsequentlydimerize,translocatetothenucleusandbindtoCISelementsupstreamoftargetgenepromoterstoregulatetranscription.ThecanonicalJAK/Statpathwayisintegraltomaintaininganormalimmunesystembystimulatingproliferation,differentiation,survivalandhostresistancetopathogens.AlteringJAK/Statsignalingtoreducecytokineinducedpro-inflammatoryresponsesrepresentsanattractivetargetforanti-inflammatorytherapies.WithintheJAK2kinasedomain,thereisaregionthathasconsiderablesequencehomologytotheregulatoryregionoftheinsulinreceptor.Amongavarietyofsites,Tyrosines1007and1008aresitesoftrans-orautophosphorylationinvivoandininvitrokinasereactions.
      ProductInformation
      FormatPurified
      Control
      • Humanovariancancercells,GM-CSF-treatedTF-1cells.
      PresentationPurifiedrabbitIgGinbuffercontaining0.1MTris-Glycine,0.15MNaCl,0.05%SodiumAzide,pH7.4.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.Formaximumrecoveryofproduct,centrifugetheoriginalvialpriortoremovingthecap.
      Applications
      ApplicationAnti-phospho-JAK2(Tyr1007/1008)Antibodydetectslevelofphospho-JAK2(Tyr1007/1008)&hasbeenpublished&validatedforuseinWB.
      KeyApplications
      • WesternBlotting
      BIOLOGicalInformation
      ImmunogenKLH-conjugated,syntheticpeptidecorrespondingtoaminoacidssurroundingphosphotyrosines1007and1008ofhumanJAK2.
      EpitopeTyr1007/1008
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityRecognizesphosphorylatedJAK2,Mr130kDa.
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      SpeciesReactivityNoteHumanandmouse.Predictedtocross-reactwithratbasedonsequencehomology.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneproductisaproteintyrosinekinaseinvolvedinaspecificsubsetofcytokinereceptorsignalingpathways.Ithasbeenfoundtobeconstituitivelyassociatedwiththeprolactinreceptorandisrequiredforresponsestogammainterferon.Micethatdonotexpressanactiveproteinforthisgeneexhibitembryoniclethalityassociatedwiththeabsenceofdefinitiveerythropoiesis.
      GeneSymbol
      • JAK2
      • OTTHUMP00000043260
      • JAK-2
      Modifications
      • Phosphorylation
      PurificationMethodProteinAPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:O60674#Tyrosinekinaseofthenon-receptortype,involvedininterleukin-3andprobablyinterleukin-23signaltransduction.
      SIZE:1132aminoacids;130674Da
      SUBUNIT:InteractswithSIRPA(Bysimilarity).InteractswithIL23R,SKB1andSTAM2.
      SUBCELLULARLOCATION:Intracytoplasmicmembrane;Peripheralmembraneprotein(Bysimilarity).Note=Whollyintracellular,possIBLymembraneassociated(Bysimilarity).
      TISSUESPECIFICITY:Expressedinblood,bonemarrowandlymphnode.
      DOMAIN:SwissProt:O60674Possessestwophosphotransferasedomains.Thesecondoneprobablycontainsthecatalyticdomain(Bysimilarity),whilethepresenceofslightdifferencessuggestadifferentrolefordomain1.
      DISEASE:SwissProt:O60674#ChromosomalaberrationsinvolvingJAK2arefoundinbothchronicandacuteformsofeosinophilic,lymphoblasticandmyeloidleukemia.Translocationt(8;9)(p22;p24)withPCM1linkstheproteinkinasedomainofJAK2tothemajorportionofPCM1.Translocationt(9;12)(p24;p13)withETV6.&DefectsinJAK2areacauseofsusceptibilitytoBudd-Chiarisyndrome[MIM:600880].Budd-Chiarisyndromeisaspectrumofdiseasestates,includinganatomicabnormalitiesandhypercoagulabledisorders,resultinginhepaticvenousoutflowocclusion.Clinicalmanifestationsobservedinthemajorityofpatientsincludehepatomegaly,rightupperquadrantpain,andaBDominalascites.&DefectsinJAK2areassociatedwithpolycythemiavera(PV)[MIM:263300].PV,themostcommonformofprimarypolycythemia,iscausedbysomaticmutationinasinglehematopoieticstemcellleADIngtoclonalhematopoiesis.PVisamyeloproliferativedisordercharacterizedpredominantlybyerythroidhyperplasia,butalsobymyeloidleukocytosis,thrombocytosis,andsplenomegaly.FamilialcasesofPVareveryrareandusuallymanifestinelderlypatients.&DefectsinJAK2genemaybeacauseofessentialthrombocythemia(ET)[MIM:187950].ETischaracterizedbyelevatedplateletlevelsduetosustainedproliferationofmegakaryocytes,andfrequentlyleadtothromboticandhaemorrhagiccomplications.&DefectsinJAK2areassociatedwithfamilialmyelofibrosis[MIM:254450].Myelofibrosiswithmyeloidmetaplasiaisamyeloproliferativediseasewithannualincidenceof0.5-1.5casesper100,000individualsandageatdiagnosisaround60(anincreasedprevalenceisnotedinAshkenaziJews).Clinicalmanifestationsdependonthetypeofbloodcellaffectedandmayincludeanemia,pallor,splenomegaly,hypermetabolicstate,petechiae,ecchymosis,bleeding,lymphadenopathy,hepatomegaly,portalhypertension.&DefectsinJAK2areacauseofacutemyelogenousleukemia(AML)[MIM:601626].AMLisamalignantdiseaseinwhichhematopoieticprecursorsarearrestedinanearlystageofdevelopment.
      SIMILARITY:Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.JAKsubfamily.&Contains1FERMdomain.&Contains1proteinkinasedomain.&Contains1SH2domain.
      MolecularWeight130kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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