UniProtSummary | FUNCTION:SwissProt:Q16620#Receptorforbrain-derivedneurotrophicfactor(BDNF),neurotrophin-3andneurotrophin-4/5butnotnervegrowthfactor(NGF).Involvedinthedevelopmentand/ormaintenanceofthenervoussystem.Thisisatyrosine-proteinkinasereceptor.KnownsubstratesfortheTRKreceptorsareSHC1,PI-3kinase,andPLC-gamma-1. SIZE:822aminoacids;91999Da SUBUNIT:Existsinadynamicequilibriumbetweenmonomeric(lowaffinity)anddimeric(highaffinity)structures.BindsSH2B2.InteractswithSQSTM1(Bysimilarity). SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:IsoformTrkBiswidelyexpressed,mainlyinthenervoustissue.IntheCNS,expressionisobservedinthecerebralcortex,hippocampus,thalamus,choroidplexus,granularlayerofthecerebellum,brainstem,andspinalcord.Intheperipheralnervoussystem,itisexpressedinmanycranialganglia,theophtalmicnerve,thevestibularsystem,multiplefacialstructures,thesuBMAxillaryglands,anddorsalrootganglia.IsoformTrkB-T1isexpressedinmultipletissues,mainlyinbrain,pancreas,kidneyandheart.IsoformTrkB-T-Shcispredominantlyexpressedinbrain. PTM:Ligand-mediatedauto-phosphorylation. SIMILARITY:SwissProt:Q16620##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Insulinreceptorsubfamily.&Contains2Ig-likeC2-type(immunoglobulin-like)domains.&Contains2LRR(leucine-rich)repeats.&Contains1proteinkinasedomain. |