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Millipore/07-225 | Anti-TrkB Antibody/07-225/200 µg
  • Millipore/07-225 | Anti-TrkB Antibody/07-225/200 µg

Millipore/07-225 | Anti-TrkB Antibody/07-225/200 µg

价格: ¥4308.00 市场价: 7180.00

货号: 07-225
品牌: Millipore
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    • Description
      CatalogueNumber07-225
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-TrkBAntibody
      AlternateNames
      • BDNF/NT-3growthfactorsreceptor
      • Neurotrophictyrosinekinasereceptortype2
      • TrkBtyrosinekinase
      • neurotrophictyrosinekinasereceptor,type2
      • tyrosinekinasereceptorB
      BackgroundInformationTheTrk(tropomyosin-receptor-kinase)proto-oncogenefamilyofreceptortyrosinekinasescontainsfourmembers,TrkA,TrkB,TrkC,andTrkE,whicharevariablyexpressedthroughoutthecentralandperipheralnervoussystems.TrkBisthehigh-affinitytothebindingbrain-derivedneurotrophicfactor(BDNF)receptorandneurotrophin-4/5NT-4/5).TrkBisautophosphorylatedonfivecytoplasmictyrosines.ThebindingofBDNFtoTrkBreceptorcausesmanyintercellularcascadestobeactivatedsuchaspromotingsurvivalofsensoryneuronsmainlythroughShcsite-independentpathways.ThesignalingactivityofthesereceptorsincludestheRas–MAPkinasepathway,andthePI3Kinasepathway.ThesereceptorsareresponsIBLeforresistancetoapoptosis,obesity,Alzheimer’sdisease,andmooddisorders.
      ProductInformation
      FormatPurified
      Control
      • Braintissue.
      PresentationPurifiedrabbitpolyclonalinbuffercontaining0.014Mphosphatebuffer,pH7.6,0.175MNaCl,0.07%sodiumazide,and30%glycerol.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20ºCfromdateofreceipt.
      Applications
      ApplicationThisAnti-TrkBAntibodyisvalidatedforuseinWBforthedetectionofTrkB.
      KeyApplications
      • WesternBlotting
      BIOLOGicalInformation
      ImmunogenTheentireextracellulardomain(correspondingtoresidues1–429)oftheratTrkBreceptor,expressedinCOScells.Theimmunizingsequencehas97%identitywithmouseTrkBand88%identitywithhumanTrkB.
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityRecognizesTrkB,Mr145kDa,aswellasanadditionalprotein,Mr90kDa,whichislikelyaTrkBdegradationproduct.
      IsotypeIgG
      SpeciesReactivity
      • Rat
      • Mouse
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryReceptorforbrain-derivedneurotrophicfactor(BDNF)[RGD].
      GeneSymbol
      • NTRK2
      • GP145-TrkB
      • TRKB
      • Trk-B
      PurificationMethodProteinAPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:Q16620#Receptorforbrain-derivedneurotrophicfactor(BDNF),neurotrophin-3andneurotrophin-4/5butnotnervegrowthfactor(NGF).Involvedinthedevelopmentand/ormaintenanceofthenervoussystem.Thisisatyrosine-proteinkinasereceptor.KnownsubstratesfortheTRKreceptorsareSHC1,PI-3kinase,andPLC-gamma-1.
      SIZE:822aminoacids;91999Da
      SUBUNIT:Existsinadynamicequilibriumbetweenmonomeric(lowaffinity)anddimeric(highaffinity)structures.BindsSH2B2.InteractswithSQSTM1(Bysimilarity).
      SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
      TISSUESPECIFICITY:IsoformTrkBiswidelyexpressed,mainlyinthenervoustissue.IntheCNS,expressionisobservedinthecerebralcortex,hippocampus,thalamus,choroidplexus,granularlayerofthecerebellum,brainstem,andspinalcord.Intheperipheralnervoussystem,itisexpressedinmanycranialganglia,theophtalmicnerve,thevestibularsystem,multiplefacialstructures,thesuBMAxillaryglands,anddorsalrootganglia.IsoformTrkB-T1isexpressedinmultipletissues,mainlyinbrain,pancreas,kidneyandheart.IsoformTrkB-T-Shcispredominantlyexpressedinbrain.
      PTM:Ligand-mediatedauto-phosphorylation.
      SIMILARITY:SwissProt:Q16620##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Insulinreceptorsubfamily.&Contains2Ig-likeC2-type(immunoglobulin-like)domains.&Contains2LRR(leucine-rich)repeats.&Contains1proteinkinasedomain.
      MolecularWeight145κDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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