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Millipore/06-574 | Anti-TrkA Antibody/06-574/200 µg
  • Millipore/06-574 | Anti-TrkA Antibody/06-574/200 µg

Millipore/06-574 | Anti-TrkA Antibody/06-574/200 µg

价格: ¥5052.00 市场价: 8420.00
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货号: 06-574
品牌: Millipore
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    • Description
      CatalogueNumber06-574
      ReplacesCBL770
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-TrkAAntibody
      AlternateNames
      • Neurotrophictyrosinekinasereceptortype
      • OncogeneTRK
      • TRK1-transformingtyrosinekinaseprotein
      • highaffinitynervegrowthfactorreceptor
      • neurotrophictyrosinekinase,receptor,type1
      • tyrosinekinasereceptorA
      BackgroundInformationTrkA,apparentmolecularweight140kDa,isahighaffinitynervegrowthfactor(NGF).TheTrkproto-oncogenefamilycontainsfourmembers,TrkA,TrkB,TrkC,andTrkE,whicharevariablyexpressedthroughoutthecentralandperipheralnervoussystems.TrkAbindstonervegrowthfactor(NGF)andautophosphorylatesontyrosineresidues(Tyr490,Tyr674,Tyr675,Tyr751andTyr785)toactivatemultipledownstreameffectorproteins.PhosphorylationatTyr490isrequiredforShcassociationandsubsequentactivationoftheRas-MAPkinase-signalingcascade,whichleadstoactivationofElk-1-dependentgenetranscriptionandneuritegrowth.PhosphorylationsatTyr674andTyr675liewithinthecatalyticdomainofTrkAtyrosinekinaseandreflectTrkkinaseactivity.Additionally,phosphorylationatTyr751isrequiredforPI3-kinaseassociationandactivationoftheAktsignalingcascade.
      ProductInformation
      FormatPurified
      Control
      • EGF-stimulatedA431cellysate,ratbraintissue.IncludedPositiveAntigenControl:Catalog#12-301,non-stimulatedA431celllysate.Add2.5μLof2-mercaptoethanol/100μLoflysateandboilfor5minutestoreducethepreparation.Load20μgofreducedlysateperlaneforminigels.
      PresentationPurifiedrabbitIgGinbuffercontaining0.02Mphosphatebuffer,pH7.6,0.25MNaCl,0.1%sodiumazide.Frozenat-20°C.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.
      HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
      Applications
      ApplicationAnti-TrkAAntibodydetectslevelofTrkA&hasbeenpublished&validatedforuseinIC,IP&WB.
      KeyApplications
      • Immunocytochemistry
      • Immunoprecipitation
      • WesternBlotting
      ApplicationNotesImmunoprecipitation:
      4μgofapreviouslotimmunoprecipitatedTrkAfrom500μgofPC-12RIPAlysate.

      Immunocytochemistry:
      10μg/mLofapreviouslotofthisantibodyshowedpositiveimmunostainingforTrkAinPC-12cellsfixedwith4%paraformaldehyde.
      BIOLOGicalInformation
      ImmunogenRabbitsimmunizedwithbacteriallyexpressedpurifiedproteincorrespondingtotheentireextracellulardomainofratTrkAreceptor.
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityRecognizesTrkA,Mr140kDa.Doesnotcross-reactwithTrkBorTrkC.
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      SpeciesReactivityNoteRat,mouseandhuman.Reactivitywithotherspecieshasnotbeenconfirmed.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesamemberoftheneurotrophictyrosinekinasereceptor(NTKR)family.Thiskinaseisamembrane-boundreceptorthat,uponneurotrophinbinding,phosphorylatesitselfandmembersoftheMAPKpathway.Thepresenceofthiskinaseleadstocelldifferentiationandmayplayaroleinspecifyingsensoryneuronsubtypes.Mutationsinthisgenehavebeenassociatedwithcongenitalinsensitivitytopain,anhidrosis,self-mutilatingbehavior,mentalretardationandcancer.Alternatetranscriptionalsplicevariantsofthisgenehavebeenfound,butonlythreehavebeencharacterizedtodate.
      GeneSymbol
      • DKFZp781I14186
      • EC2.7.10.1
      • MTC
      • OTTHUMP00000038736
      • TRK
      • TRK1
      • TRKA
      • Trk-A
      • p140-TrkA
      PurificationMethodProteinAPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P04629#Requiredforhigh-affinitybindingtonervegrowthfactor(NGF),neurotrophin-3andneurotrophin-4/5butnotbrain-derivedneurotrophicfactor(BDNF).KnownsubstratesfortheTrkreceptorsareSHC1,PI3-kinase,andPLC-gamma-1.Hasacrucialroleinthedevelopmentandfunctionofthenociceptivereceptionsystemaswellasestablishmentofthermalregulationviasweating.ActivatesERK1byeitherSHC1-orPLC-gamma-1-dependentsignalingpathway.
      SIZE:796aminoacids;87497Da
      SUBUNIT:Existsinadynamicequilibriumbetweenmonomeric(lowaffinity)anddimeric(highaffinity)structures.BindsSH2B2.InteractswithSQSTM1whichbridgesNTRK1toNGFR(Bysimilarity).
      SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein(Bysimilarity).Note=EndocytosedtotheendosomesupontreatmentofcellswithNGF(Bysimilarity).
      TISSUESPECIFICITY:IsoformTrkA-IIisprimarilyexpressedinneuronalcells;isoformTrkA-Iisfoundinnon-neuronaltissues.
      PTM:Ligand-mediatedauto-phosphorylation.InteractionwithSQSTM1isphosphotyrosine-dependent.
      DISEASE:SwissProt:P04629#DefectsinNTRK1areacauseofcongenitalinsensitivitytopainwithanhidrosis(CIPA)[MIM:256800].CIPAischaracterizedbyacongenitalinsensitivitytopain,anhidrosis(absenceofsweating),absenceofreactiontonoxiousstimuli,self-mutilatingbehavior,andmentalretardation.ThisrareautosomalrecessivedisorderisalsoknownascongenitalsensoryneuropathywithanhidrosisorhereditarysensoryandautonomicneuropathytypeIVorfamilialdysautonomiatypeII.&ChromosomalaberrationsinvolvingNTRK1areacauseofthyroidpapillarycarcinoma(PACT)[MIM:188550].Translocationt(1;3)(q21;q11)withTFGgeneratestheTRKT3(TRK-T3)transcriptbyfusingTFGtothe3"-endofNTRK1;arearrangementwithTPM3generatestheTRKtranscriptbyfusingTPM3tothe3"-endofNTRK1.&ChromosomalaberrationsinvolvingNTRK1areacauseofthyroidpapillarycarcinoma(PACT)[MIM:188550].IntrachromosomalrearrangementthatlinkstheproteinkinasedomainofNTRK1tothe5"-endoftheTPRgeneformsthefusionproteinTRK-T1.TRK-T1isa55kDaproteinreactingwithantibodiesagainsttheC-terminusoftheNTRK1protein.
      SIMILARITY:SwissProt:P04629##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Insulinreceptorsubfamily.&Contains2Ig-likeC2-type(immunoglobulin-like)domains.&Contains3LRR(leucine-rich)repeats.&Contains1proteinkinasedomain....hide»seemore»
      MolecularWeight140kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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