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Tocris/(<em>R</em>)-(-)-α-Methylhistamine dihydrobromide/0569/50/50 mg

Tocris/(R)-(-)-α-Methylhistamine dihydrobromide/0569/50/50 mg

价格: ¥6420.00 市场价: 10700.00

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货号: 0569/50

品牌: Tocris

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Description: Potent, standard H₃ agonist

Chemical Name: (R)-(-)-α-Methyl-1H-imidazole-4-ethanamine dihydrobromide

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Very potent, high affinity H₃ agonist (K_D = 50.3 nM) that displays > 200-fold selectivity over H₄ receptors. Inhibits H₃-mediated histamine synthesis and release in the CNS and stimulates H₄-mediated eosinophil shape change (EC₅₀ = 66 nM). Part of the Histamine H₃ Receptor Tocriset™. (S)-(+)-α-Methylhistamine dihydrobromide (Cat. No. 0572) also available.

Technical Data

M. Wt	287
Formula	C₆H₁₁N₃.2HBr
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	868698-49-1
PubChem ID	45037031
InChI Key	RWHNAAABSGVRDT-ZJIMSODOSA-N
Smiles	N[C@H](C)CC1=CNC=N1.Br.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	28.7	100

Preparing Stock Solutions

The following data is based on the product molecular weight 287. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.48 mL	17.42 mL	34.84 mL
5 mM	0.7 mL	3.48 mL	6.97 mL
10 mM	0.35 mL	1.74 mL	3.48 mL
50 mM	0.07 mL	0.35 mL	0.7 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Buckland et al (2003) Histamine induces cytoskeletal changes in human eosinophils via the H₄ receptor. Br.J.Pharmacol. 140 1117 PMID: 14530216

Hew et al (1990) Characterization of histamine-H₃ receptors in guinea pig ileum with H₃-selective ligands. Br.J.Pharmacol. 101 621 PMID: 1963802

Oishi et al (1989) Effects of histamine H₃-agonist (R)-α-methylhistamine and the antagonist thioperamide on histamine modulation in the mouse and rat brain. J.Neurochem. 52 1388 PMID: 2540269

Schwartz et al (1990) A third histamine receptor subtype - characterization, localization and functions of the H₃-receptor. Agents Actions 30 13 PMID: 1695431

Shahid et al (2009) Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review. Open Immunol.J. 2 9 PMID:

Keywords: (R)-(-)-alpha-Methylhistamine dihydrobromide, supplier, Potent, H3, agonists, Receptors, Histamine, histaminergic, (R)-(-)-alpha-Methylhistamine, dihydrobromide, Histamine, H3, Receptors, Histamine, H3, Receptors, Tocris Bioscience

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