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Tocris/8-Hydroxy-DPAT hydrobromide/0529/10/10 mg

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货号: 0529

品牌: Tocris

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Description: Selective 5-HT_1A agonist; also has moderate affinity for 5-HT₇

Alternative Names: 8-OH-DPAT hydrobromide

Chemical Name: (±)-8-Hydroxy-2-dipropylaminotetralin hydrobromide

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

The standard selective 5-HT_1A agonist. Also has moderate affinity for 5-HT₇ receptors (pK_i is 6.6 at the human 5-HT₇ receptor expressed in HEK 293 cells). Reduces hippocampal 5-HT levels following systemic administration in rats in vivo. (R)-(+)-8-Hydroxy-DPAT hydrobromide (Cat. No. 1080) and 7-Hydroxy-DPAT hydrobromide (Cat. No. 0706) also available.

Technical Data

M. Wt	328.29
Formula	C₁₆H₂₅NO.HBr
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	76135-31-4
PubChem ID	6917794
InChI Key	BATPBOZTBNNDLN-UHFFFAOYSA-N
Smiles	Br.CCCN(CCC)C1CCC2=CC=CC(O)=C2C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	phosphate buffered saline	4.92	15mM with gentle warming
	ethanol	1.64	5
	water	6.57	20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 328.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.05 mL	15.23 mL	30.46 mL
5 mM	0.61 mL	3.05 mL	6.09 mL
10 mM	0.3 mL	1.52 mL	3.05 mL
50 mM	0.06 mL	0.3 mL	0.61 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Helton and Colbert (1994) Alteration of in-vitro 5-HT receptor pharmacology as a function of multiple treatment with 5-hydroxytryptamine of 8-hydroxy-2-(di-N-propylamino)tetralin in rat isolated aorta, uterus and fundus, and guinea pig isolated trachea. J.Pharm.Pharmacol. 46 902 PMID: 7897596

Middlemiss et al (1983) 8-OH-DPAT discriminates between subtypes of the 5HT₁ recognition site. Eur.J.Pharmacol. 90 151 PMID: 6223827

Wood et al (2000) Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT₇ receptor. Eur.J.Pharmacol. 396 1 PMID: 10822046

Yoshitake and Kehr (2004) Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life Sci. 74 2865 PMID: 15050424

Keywords: 8-Hydroxy-DPAT hydrobromide, supplier, moderate, affinity, 5-HT7, 5-HT1A, agonists, Selective, Serotonin, Receptors, 5-Hydroxytryptamine, 5-HT1, 8-OH-DPAT, hydrobromide, 5-HT1A, Receptors, Tocris Bioscience

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