Immunogen | 6HisfusionproteincorrespondingtomousePML(promyelocyticleukemiaprotein) |
Clone | 36.1-104 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Mouse |
Specificity | RecognizesPML. |
Isotype | IgG |
SpeciesReactivity | |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Theproteinencodedbythisgeneisamemberofthetripartitemotif(TRIM)family.TheTRIMmotifincludesthreezinc-bindingdomains,aRING,aB-boxtype1andaB-boxtype2,andacoiled-coilregion.Thisphosphoproteinlocalizestonuclearbodieswhereitfunctionsasatranscriptionfactorandtumorsuppressor.Itsexpressioniscell-cyclerelatedanditregulatesthep53responsetooncogenicsignals.Thegeneisofteninvolvedinthetranslocationwiththeretinoicacidreceptoralphageneassociatedwithacutepromyelocyticleukemia(APL).Extensivealternativesplicingofthisgeneresultsinseveralvariationsoftheprotein"scentralandC-terminalregions;allvariantsencodethesameN-terminus.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenidentified. |
GeneSymbol | |
PurificationMethod | ProteinGPurified |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P29590#Probabletranscriptionfactor.MayplayanimportantroleinrecruitmentofELF4intoPMLnuclearbodies. SIZE:882aminoacids;97517Da SUBUNIT:InteractswithSIRT1,TOPBP1,TRIM27andTRIM69.InteractswiththeC-terminusofELF4.InteractswithLassavirusZproteinandrABIesvirusphosphoprotein(Bysimilarity). SUBCELLULARLOCATION:Nucleus.Note=LocalizedtoPMLnuclearbodies. PTM:Ubiquitinated;mediatedbySIAH1orSIAH2andleADIngtoitssubsequentproteasomaldegradation. DISEASE:SwissProt:P29590#AchromosomalaberrationinvolvingPMLmaybeacauseofacutepromyelocyticleukemia(APL).Translocationt(15;17)(q21;q21)withRARA.ThePMLbreakpoints(typeAandtypeB)lieoneithersideofanalternativelysplicedexon. SIMILARITY:SwissProt:P29590##Contains2Bbox-typezincfingers.&Contains1RING-typezincfinger. |
MolecularWeight | 90-106kDa |