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Tocris/Dihydroergotamine mesylate/0475/100/100 mg

价格: ¥1260.00 市场价: 2100.00

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货号: 0475/100

品牌: Tocris

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Description: Partial α agonist. Non-selective

Chemical Name: 9,10-Dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotaman-3',6',18-trione mesylate

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Partial α-adrenergic agonist. Partial D₂ dopaminergic receptor agonist. Competitive 5-HT antagonist.

Compound Libraries

Dihydroergotamine mesylate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	679.79
Formula	C₃₃H₃₇N₅O₅.CH₃SO₃H
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	6190-39-2
PubChem ID	71171
InChI Key	ADYPXRFPBQGGAH-UMYZUSPBSA-N
Smiles	CS(=O)(O)=O.[H][C@]4([C@@]([H])3C[C@@H]([C@@](N[C@@]5(C)C(N([C@@]([H])(CC8=CC=CC=C8)C(N7[C@]([H])6CCC7)=O)[C@@]6(O)O5)=O)=O)CN4C)CC1=CNC2=C1C3=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	67.97	100

Preparing Stock Solutions

The following data is based on the product molecular weight 679.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.47 mL	7.36 mL	14.71 mL
5 mM	0.29 mL	1.47 mL	2.94 mL
10 mM	0.15 mL	0.74 mL	1.47 mL
50 mM	0.03 mL	0.15 mL	0.29 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

de Boer et al (1991) Carotid vascular effects of ergotamine and dihydroergotamine in the pig: no exclusive mediation via 5-HT₁-like receptors. Br.J.Pharmacol. 104 183 PMID: 1664762

Doggrell et al (1992) Further analysis of the inhibitory effects of dihydroergotamine, cyproheptadine and ketanserin on the responses of the rat aorta to 5-hydroxytryptamine. J.Auton.Pharmacol. 12 223 PMID: 1512277

Lesage et al (1998) Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT_1B and 5-HT_1D receptors expressed in various mammalian cell lines. Br.J.Pharmacol. 123 1655 PMID: 9605573

Villalon et al (1992) Effects of S9977 and dihydroergotamine in an animal experimental model for migraine. Pharmacol.Res. 25 125 PMID: 1635891

Keywords: Dihydroergotamine mesylate, supplier, 5-HT, antagonists, partial, agonists, a-adrenergic, α-adrenergic, alpha-adrenergic, dopaminergic, D2, receptors, Partial, D2-like, alpha, Non-Selective, Serotonin, 5-HT3, Receptors, 5-Hydroxytryptamine, Dopamine, α-adrenoceptors, α-adrenoceptor, alpha-adrenocep, Non-selective, Adrenergic, Alpha, Receptors, Non-selective, Dopamine, Non-selective, 5-HT, 5-HT3, Receptors, Non-selective, Adrenergic, Alpha, Receptors, Tocris Bioscience

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