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Tocris/ML 9 hydrochloride/0431/50/50 mg

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货号: 0431/50

品牌: Tocris

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Description: Myosin light chain kinase inhibitor

Chemical Name: 1-(5-Chloronaphthalenesulfonyl)homopiperazine hydrochloride

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective MLCK inhibitor (K_i values are 4, 32 and 54 μM for MLCK, PKA and PKC respectively). Also inhibits STIM1-plasma membrane interactions, preventing store-operated Ca²⁺ entry (SOCE).

Compound Libraries

ML 9 hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	361.29
Formula	C₁₅H₁₇ClN₂O₂S.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	105637-50-1
PubChem ID	108047
InChI Key	ZNRYCIVTNLZOGI-UHFFFAOYSA-N
Smiles	Cl.ClC1=C2C=CC=C(C2=CC=C1)S(=O)(=O)N1CCCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.03	25

Preparing Stock Solutions

The following data is based on the product molecular weight 361.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.77 mL	13.84 mL	27.68 mL
5 mM	0.55 mL	2.77 mL	5.54 mL
10 mM	0.28 mL	1.38 mL	2.77 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Hidaka and Koybashi (1992) Pharmacology of protein kinase inhibitors. Annu.Rev.Pharmacol.Toxicol. 32 377 PMID: 1605572

Seto et al (1991) Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle. Eur.J.Pharmacol. 195 267 PMID: 1874276

Varnai et al (2009) STIM and Orai: the long-awaited constituents of store-operated calcium entry. TiPS 30 118 PMID: 19187978

Hidaka and Hagiwara (1987) Pharmacology of the isoquinoline sulfonamide protein kinase C inhibitors. Trends Pharmacol.Sci. 8 162 PMID:

Keywords: ML 9 hydrochloride, supplier, Myosin, light, chain, kinase, inhibitors, inhibits, STIM1-plasma, membrane, interaction, Kinases, Ca2+, Binding, Protein, modulators, Calmodulin, CaM, Calcium, Signaling, Signalling, Store, Operated, Channels, STIM-Orai, ML9, hydrochloride, MLCK, Myosin, Light, Chain, Kinase, Calcium, Binding, Protein, Myosin, STIM-Orai, Channels, Myosin, Light, Chain, Kinase, Tocris Bioscience

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