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Tocris/UK 14,304/0425/50/50 mg

价格: ¥5820.00 市场价: 9700.00

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货号: 0425/50

品牌: Tocris

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Description: α₂ agonist

Chemical Name: 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Full α₂ adrenergic agonist. Centrally active following systemic administration in vivo. Also available as part of the α₂-Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™. Water soluble salt version UK 14,304 tartrate (Cat. No. 2466) also available.

Compound Libraries

UK 14,304 is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	292.14
Formula	C₁₁H₁₀BrN₅
Storage	Store at RT
CAS Number	59803-98-4
PubChem ID	2435
InChI Key	XYLJNLCSTIOKRM-UHFFFAOYSA-N
Smiles	BrC1=C(NC2=NCCN2)C=CC2=NC=CN=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility	Soluble to 100 mM in DMSO

Solubility

Soluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 292.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.42 mL	17.12 mL	34.23 mL
5 mM	0.68 mL	3.42 mL	6.85 mL
10 mM	0.34 mL	1.71 mL	3.42 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Andorn et al (1988) Specific [³H]UK-14,304 binding in human cortex occurs at multiple high affinity states with α₂-adrenergic selectivity and different affinities for GTP. Life Sci. 43 1805 PMID: 2904634

Chopin et al (1999) Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J.Pharmacol.Exp.Ther. 288 798 PMID: 9918591

Macdonald et al (1997) Gene trageting - homing in on α₂-adrenoceptor-subtype function. TiPS 18 211 PMID: 9227000

Keywords: UK 14,304, supplier, α2-adrenoceptor, alpha2-adrenoceptors, a2-adrenoceptors, agonists, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, Receptors, UK14304, Adrenergic, Alpha-2, Receptors, Adrenergic, Alpha-2, Receptors, Tocris Bioscience

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