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Millipore/04-1046 | Anti-Notch1 (Cytoplasmic) Antibody, clone EP1238Y, Rabbit | 04-1046/04-1046/100 µL
  • Millipore/04-1046 | Anti-Notch1 (Cytoplasmic) Antibody, clone EP1238Y, Rabbit | 04-1046/04-1046/100 µL

Millipore/04-1046 | Anti-Notch1 (Cytoplasmic) Antibody, clone EP1238Y, Rabbit | 04-1046/04-1046/100 µL

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货号: 04-1046
品牌: Millipore
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    • Description
      CatalogueNumber04-1046
      DescriptionAnti-Notch1(Cytoplasmic)Antibody,cloneEP1238Y,Rabbit|04-1046
      AlternateNames
      • Translocation-associatednotchproteinTAN-1
      • neurogeniclocusnotchhomologprotein1
      BackgroundInformationNotchisthereceptorforDeltaandJaggedligands,whichcauseproteolysisofnotchtoliberatetheintracellulardomain.ThatdomaintranslocatestothenucleusandinitiatestranscriptioneventsbybindingtheDNAbindingproteinCSL.Thenotchfamilymembersareinvolvedinnumerousdifferentiationandcelllineagedeterminationsteps.
      ProductInformation
      FormatPurified
      Control
      • Hek293celllysates
      PresentationRabbitmonoclonalIgGinbuffercontaining50mMTris-Glycine(pH7.4),0.18MNaClcontaining40%Glycerol,0.25%sodiumazide,0.25mMEDTA,25mMCitricAcid,and0.5%BSA.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20ºCfromdateofreceipt.
      HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
      Applications
      ApplicationPleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.Anti-Notch1(Cytoplasmic)Antibody,cloneEP1238Y,RabbitdetectslevelofNotch1(Cytoplasmic)&hasbeenpublished&validatedforuseinWB,IC,IH.
      KeyApplications
      • WesternBlotting
      • Immunocytochemistry
      • Immunohistochemistry
      ApplicationNotesImmunohistochemistryAnalysis:1:50-100dilutionfromapreviouslotdetectedNotch1inHumanfetallungtissue.
      BIOLOGicalInformation
      ImmunogenSyntheticpeptidecorrespondingtothecytoplasmicdomainofhumanNotch1
      EpitopeCytoplasmicDomain
      CloneEP1238Y
      HostRabbit
      SpecificityThisantibodyrecognizesthecytoplasmicdomainofNotch1
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Mouse
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesamemberoftheNotchfamily.MembersofthisType1transmembraneproteinfamilysharestructuralcharacteristicsincludinganextracellulardomainconsistingofmultipleepidermalgrowthfactor-like(EGF)repeats,andanintracellulardomainconsistingofmultiple,differentdomaintypes.Notchfamilymembersplayaroleinavarietyofdevelopmentalprocessesbycontrollingcellfatedecisions.TheNotchsignalingnetworkisanevolutionarilyconservedintercellularsignalingpathwaywhichregulatesinteractionsbetweenphysicallyadjacentcells.InDrosophilia,notchinteractionwithitscell-boundligands(delta,serrate)establishesanintercellularsignalingpathwaythatplaysakeyroleindevelopment.Homologuesofthenotch-ligandshavealsobeenidentifiedinhuman,butpreciseinteractionsbetweentheseligandsandthehumannotchhomologuesremaintobedetermined.Thisproteiniscleavedinthetrans-Golginetwork,andpresentedonthecellsurfaceasaheterodimer.Thisproteinfunctionsasareceptorformembraneboundligands,andmayplaymultiplerolesduringdevelopment.[providedbyRefSeq]
      GeneSymbol
      • TAN1
      • hN1
      • notch1
      UniProtNumber
      UniProtSummaryFUNCTION:Functionsasareceptorformembrane-boundligandsJagged1,Jagged2andDelta1toregulatecell-fatedetermination.Uponligandactivationthroughthereleasednotchintracellulardomain(NICD)itformsatranscriptionalactivatorcomplexwithRBP-Jkappaandactivatesgenesoftheenhancerofsplitlocus.Affectstheimplementationofdifferentiation,proliferationandapoptoticprograms.Maybeimportantfornormallymphocytefunction.Inalteredform,maycontributetotransformationorprogressioninsomeT-cellneoplasms.InvolvedinthematurationofbothCD4+andCD8+cellsinthethymus.MaybeimportantforfolliculardifferentiationandpossIBLycellfateselectionwithinthefollicle.Duringcerebellardevelopment,mayfunctionasareceptorforneuronalDNERandmaybeinvolvedinthedifferentiationofBergmanngliaBysimilarity.
      SUBUNITSTRUCTURE:HeterodimerofaC-terminalfragmentN(TM)andanN-terminalfragmentN(EC)whichareprobablylinkedbydisulfidebonds.InteractswithDNER,DTX1,DTX2andRBPSUH.AlsointeractswithMAML1,MAML2andMAML3whichactastranscriptionalcoactivatorsforNOTCH1.Ref.6Ref.7Ref.8
      SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneproteinBysimilarity.
      Notch1intracellulardomain:NucleusBysimilarity.Note=FollowingproteolyticalprocessingNICDistranslocatedtothenucleusBysimilarity.
      TISSUESPECIFICTY:Infetaltissuesmostabundantinspleen,brainstemandlung.Alsopresentinmostadulttissueswhereitisfoundmainlyinlymphoidtissues.
      PTM:Synthesizedintheendoplasmicreticulumasaninactiveformwhichisproteolyticallycleavedbyafurin-likeconvertaseinthetrans-Golginetworkbeforeitreachestheplasmamembranetoyieldanactive,ligand-accessibleform.CleavageresultsinaC-terminalfragmentN(TM)andaN-terminalfragmentN(EC).Followingligandbinding,itiscleavedbyTNF-alphaconvertingenzyme(TACE)toyieldamembrane-associatedintermediatefragmentcallednotchextracellulartruncation(NEXT).Thisfragmentisthencleavedbypresenilindependentgamma-secretasetoreleaseanotch-derivedpeptidecontainingtheintracellulardomain(NICD)fromthemembraneBysimilarity.
      PhosphorylatedBysimilarity.
      INVOLVEMENTINDISEASE:NOTCH1truncationisassociatedwithT-cellacutelymphoblasticleukemia.Ref.13
      DefectsinNOTCH1areacauseofaorticvalvedisease[MIM:109730].Thedisorderconsistsofanearlydevelopmentaldefectintheaorticvalveandalaterde-repressionofcalciumdepositionthatcausesprogressiveaorticvalvedisease.CalcificationoftheaorticvalveisthethirdleADIngcauseofheartdiseaseinadults.Theincidenceincreaseswithage,anditisoftenassociatedwithabicUSPidaorticvalvepresentin1-2%ofthepopulation.
      SEQUENCESIMILARITIES:BelongstotheNOTCHfamily.
      Contains5ANKrepeats.
      Contains36EGF-likedomains.
      Contains3LNR(Lin/Notch)repeats.
      MolecularWeight~125kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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