Immunogen | SyntheticpeptidecorrespondingtoresiduesinthetaildomainofhumanNeurofilament-66. |
Epitope | TailDomain |
Clone | EP676Y |
Host | Rabbit |
Specificity | ThisantibodyrecognizesNeurofilament-66atandaroundthetaildomain. |
Isotype | IgG |
SpeciesReactivity | |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | NeurofilamentsaretypeIVintermediatefilamentheteropolymerscomposedoflight,medium,andheavychains.Neurofilamentscomprisetheaxoskeletonandtheyfunctionallymaintaintheneuronalcaliber.Theymayalsoplayaroleinintracellulartransporttoaxonsanddendrites.Thisgeneisamemberoftheintermediatefilamentfamilyandisinvolvedinthemorphogenesisofneurons. |
GeneSymbol | - Alpha-Inx
- FLJ18662
- FLJ57501
- MGC12702
- NEF5
- NF-66
- Neurofilament-66
- OTTHUMP00000020403
- TXBP-1
|
PurificationMethod | Unpurified |
UniProtNumber | |
UniProtSummary | FUNCTION:Class-IVneuronalintermediatefilamentthatisabletoself-assemble.Itisinvolvedinthemorphogenesisofneurons.ItmayformanindependentstructuralnetworkwithouttheinvolvementofotherneurofilamentsoritmaycooperatewithNF-LtoformthefilamentousbackbonetowhichNF-MandNF-Hattachtoformthecross-bridges. TISSUESPECIFICITY:FoundpredominantlyinadultCNS. DEVELOPMENTALSTAGE:Expressedinbrainasearlyasthe16thweekofgestation,andincreasedrapidlyandreachedasteadystatelevelbythe18thweekofgestation. PTM:O-glycosylatedBysimilarity. PhosphorylateduponDNAdamage,probablybyATMorATR. SEQUENCESIMILARITIES:Belongstotheintermediatefilamentfamily. |
MolecularWeight | ~66kDa |