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Tocris/(<em>S</em>)-3-Carboxy-4-hydroxyphenylglycine/0329/10/10 mg

Tocris/(S)-3-Carboxy-4-hydroxyphenylglycine/0329/10/10 mg

价格: ¥4428.00 市场价: 7380.00

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货号: 0329/10

品牌: Tocris

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Description: Group I antagonist/group II agonist

Alternative Names: (S)-3C4HPG

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Mixed group I metabotropic glutamate receptor antagonist and group II mGlu agonist. (R)-3-Carboxy-4-hydroxyphenylglycine (Cat. No. 0328) also available.

Technical Data

M. Wt	211.17
Formula	C₉H₉NO₅
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	55136-48-6
PubChem ID	5311460
InChI Key	CHZBCZTXSTWCIG-ZETCQYMHSA-N
Smiles	OC1=C(C(O)=O)C=C([C@]([H])(N)C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	phosphate buffered saline	5.28	25
	1eq. NaOH	21.12	100
	water	5.28	25

Preparing Stock Solutions

The following data is based on the product molecular weight 211.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.74 mL	23.68 mL	47.36 mL
5 mM	0.95 mL	4.74 mL	9.47 mL
10 mM	0.47 mL	2.37 mL	4.74 mL
50 mM	0.09 mL	0.47 mL	0.95 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Hayashi et al (1994) Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor sub-types. J.Neurosci. 14 3370 PMID: 8182479

Sekiyama et al (1996) Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 117 1493 PMID: 8730745

Watkins and Collingridge (1994) Phenylglycine derivatives as antagonists of metabotropic glutamate receptors. TiPS 15 333 PMID: 7992387

Watkins et al (1987) Recent advances in the pharmacology of excitatory amino acids. Excitatory Amino Acid Transmission. Eds. Hicks, Lo 19-26 PMID:

Keywords: (S)-3-Carboxy-4-hydroxyphenylglycine, supplier, Group, I, antagonists, group, II, agonists, Selective, mGlur, Receptors, mGlu1, mGlu5, mGluR1, mGluR5, Glutamate, Metabotropic, mGlu2, mGlu3, mGluR2, mGluR3, (S)-3C4HPG, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, II, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience

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