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Tocris/(<em>S</em>)-4-Carboxyphenylglycine/0323/50/50 mg

Tocris/(S)-4-Carboxyphenylglycine/0323/50/50 mg

价格: ¥13260.00 市场价: 22100.00

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货号: 0323/50

品牌: Tocris

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Description: Competitive group I mGlu antagonist/weak group II agonist

Alternative Names: (S)-4CPG

Purity: ≥99%

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Competitive group I metabotropic glutamate receptor antagonist, with selectivity for mGlu_1a/1a over mGlu_5a/5b. (RS)-4-Carboxyphenylglycine (Cat. No. 0321) and (R)-4-Carboxyphenylglycine (Cat. No. 0322) also available.

Technical Data

M. Wt	195.17
Formula	C₉H₉NO₄
Storage	Store at RT
Purity	≥99%
CAS Number	134052-73-6
PubChem ID	5311459
InChI Key	VTMJKPGFERYGJF-ZETCQYMHSA-N
Smiles	[H][C@@](N)(C(O)=O)C1=CC=C(C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH	19.52	100mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 195.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.12 mL	25.62 mL	51.24 mL
5 mM	1.02 mL	5.12 mL	10.25 mL
10 mM	0.51 mL	2.56 mL	5.12 mL
50 mM	0.1 mL	0.51 mL	1.02 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Birse et al (1993) Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system. Neuroscience 52 481 PMID: 7680790

Brabet et al (1995) Phenylglycine derivatives discriminate between mGluR1-and mGluR5-mediated responses. Neuropharmacology 34 895 PMID: 8532171

Doherty et al (1999) Antagonist activity of α-substituted 4-carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells. Br.J.Pharmacol. 126 205 PMID: 10051137

Eaton et al (1993) Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine (CPG) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG). Eur.J.Pharmacol. 244 195 PMID: 8381746

Keywords: (S)-4-Carboxyphenylglycine, supplier, competitive, Group, I, mGlur, antagonists, weak, group, II, agonists, Competitive, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, mGlu1, mGlu5, mGluR1, mGluR5, (S)-4CPG, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, II, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience

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