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Tocris/(<em>S</em>)-4-Carboxy-3-hydroxyphenylglycine/0320/10/10 mg

Tocris/(S)-4-Carboxy-3-hydroxyphenylglycine/0320/10/10 mg

价格: ¥3948.00 市场价: 6580.00

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货号: 0320/10

品牌: Tocris

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Description: Group I antagonist/group II agonist

Alternative Names: (S)-4C3HPG

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Competitive antagonist at group I mGlu_1a/1a receptors, mixed effect at mGlu_5a/5b receptors; agonist at group II metabotropic glutamate receptors. (RS)-4-Carboxy-3-hydroxyphenylglycine (Cat. No. 0310) also available.

Technical Data

M. Wt	211.17
Formula	C₉H₉NO₅
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	85148-82-9
PubChem ID	5311455
InChI Key	GXZSAQLJWLCLOX-ZETCQYMHSA-N
Smiles	OC1=C(C(O)=O)C=CC([C@]([H])(N)C(O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. NaOH	21.12	100
	water	1.06	5

Preparing Stock Solutions

The following data is based on the product molecular weight 211.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.74 mL	23.68 mL	47.36 mL
5 mM	0.95 mL	4.74 mL	9.47 mL
10 mM	0.47 mL	2.37 mL	4.74 mL
50 mM	0.09 mL	0.47 mL	0.95 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Birse et al (1993) Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system Neuroscience 52 481 PMID: 7680790

Hayashi et al (1994) Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor sub-types. J.Neurosci. 14 3370 PMID: 8182479

Kingston et al (1995) Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects mGluR1α and mGluR5a subtypes. Neuropharmacology 34 887 PMID: 8532170

Sekiyama et al (1996) Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 117 1493 PMID: 8730745

Keywords: (S)-4-Carboxy-3-hydroxyphenylglycine, supplier, competitive, Group, I, antagonists, group, II, agonists, mGlur, Receptors, mGlu1, mGlu5, mGluR1, mGluR5, Glutamate, Metabotropic, mGlu2, mGlu3, mGluR2, mGluR3, (S)-4C3HPG, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, II, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience

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