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Tocris/(<em>S</em>)-(-)-HA-966/0282/10/10 mg

Tocris/(S)-(-)-HA-966/0282/10/10 mg

价格: ¥1668.00 市场价: 2780.00

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货号: 0282/10

品牌: Tocris

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Description: NMDA antagonist/partial agonist

Chemical Name: (S)-(-)-3-Amino-1-hydroxypyrrolidin-2-one

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Possesses potent sedative and ataxic action, probably through disruption of striatal dopaminergic mechanisms. R-enantiomer (Cat. No. 0281) also available.

Technical Data

M. Wt	116.12
Formula	C₄H₈N₂O₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	111821-58-0
PubChem ID	183351
InChI Key	HCKUBNLZMKAEIN-VKHMYHEASA-N
Smiles	N[C@H]1CCN(O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility	Soluble to 100 mM in water

Solubility

Soluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 116.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	8.61 mL	43.06 mL	86.12 mL
5 mM	1.72 mL	8.61 mL	17.22 mL
10 mM	0.86 mL	4.31 mL	8.61 mL
50 mM	0.17 mL	0.86 mL	1.72 mL

Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service

Safety Datasheet

References

References are publications that support the products' biological activity.

Grobaski et al (1997) Responses of rat substantia nigra dopamine-containing neurones to (-)-HA-966 in vitro. Br.J.Pharmacol. 120 575 PMID: 9051293

Shepard and Lehmann (1992) (±)-1-Hydroxy-3-aminopyrrolidone-2 (HA-966) inhibits the activity of substantia nigra dopamine neurons through a non-N-methyl-D-aspartate receptor mediated mechanism. J.Pharmacol.Exp.Ther. 261 387 PMID: 1578355

Singh et al (1990) Enantiomers of HA-966 (3-amino-1-hydroxypyrrolidin-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA966 is a potent γ-butyrolactone-like sedative. Proc.Natl.Acad.Sci.U.S.A. 87 347 PMID: 2153294

Keywords: (S)-(-)-HA-966, supplier, NMDA, antagonists, partial, agonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlu, Ionotropic, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience

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